GPR137B - G protein-coupled receptor 137B Gene

Homo sapiens

Also known as TM7SF1

Gene ID: 7107 | Gene type: protein coding

About GPR137B

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:236,142,539-236,208,907 (from NCBI)

This gene has 5 transcripts (splice variants), 259 orthologues and 2 paralogues. Ubiquitous expression in kidney (RPKM 12.9), brain (RPKM 8.4) and 23 other tissues.

Summary

Involved in several processes, including positive regulation of TORC1 signaling; positive regulation of protein localization to lysosome; and regulation of GTPase activity. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR137B Products(1)

mRNA	Protein	Name
NM_003272.4	NP_003263.1	integral membrane protein GPR137B

Protein Preferred Names

Protein Names

integral membrane protein GPR137B

transmembrane 7 superfamily member 1 (upregulated in kidney)

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 60

RP60	Retinitis Pigmentosa, Type 60

Ceroid Lipofuscinosis, Neuronal, 1

Neuronal Ceroid Lipofuscinosis 1	CLN1
Infantile Neuronal Ceroid Lipofuscinosis	Cln1 Disease
Santavuori-Haltia Disease	Ceroid Lipofuscinosis, Neuronal, 1, Variable Age At Onset
Neuronal Ceroid Lipofuscinosis 1 Variable Age Of Onset	Ceroid Lipofuscinosis Neuronal 1
Cln1 Variable Age At Onset	Infantile Batten Disease
Neuronal Ceroid Lipofuscinosis, Infantile	Hagberg-Santavuori Disease
Incl	Juvenile Neuronal Ceroid Lipofuscinosis With Granular Osmiophilic Deposits
Neuronal Ceroid Lipofuscinosis With Variable Age At Onset	Santavuori Disease
Lipofuscinosis, Ceroid, Neuronal, Type 1	Ceroid Lipofuscinosis, Neuronal 1, Infantile

Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib	IGHD1B
Ighd Ib	Growth Hormone Deficiency, Isolated, Type Ib
Congenital Ighd Type Ib	Congenital Isolated Gh Deficiency Type Ib
Congenital Isolated Growth Hormone Deficiency Type Ib	Dwarfism Of Sindh
Pituitary Dwarfism I	Isolated Growth Hormone Deficiency Type 1b
Ighd 1b	Growth Hormone Deficiency, Isolated, 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05659	GPR137B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GPR137B	MGD	MGI:1891463
Macaca mulatta	GPR137B	VGNC	VGNC:72930
Felis catus	GPR137B	VGNC	VGNC:62673
Bos taurus	GPR137B	VGNC	VGNC:29551
Rattus norvegicus	GPR137B	RGD	RGD:1307342
Canis familiaris	GPR137B	VGNC	VGNC:41398

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