TPD52L1 - TPD52 like 1 Gene

Homo sapiens

Also known as D53; TPD53

Gene ID: 7164 | Gene type: protein coding

About TPD52L1

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:125,153,773-125,264,407 (from NCBI)

This gene has 17 transcripts (splice variants), 202 orthologues and 3 paralogues. Broad expression in adrenal (RPKM 40.8), salivary gland (RPKM 18.6) and 14 other tissues.

Summary

This gene encodes a member of a family of proteins that contain coiled-coil domains and may form hetero- or homomers. The encoded protein is involved in cell proliferation and calcium signaling. It also interacts with the mitogen-activated protein kinase kinase kinase 5 (MAP3K5/ASK1) and positively regulates MAP3K5-induced Apoptosis. Multiple alternatively spliced transcript variants have been observed. [provided by RefSeq, Jan 2016]

TPD52L1 Products(8)

mRNA	Protein	Name
NM_001003395.3	NP_001003395.1	tumor protein D53 isoform 2
NM_001003396.3	NP_001003396.1	tumor protein D53 isoform 3
NM_001003397.3	NP_001003397.1	tumor protein D53 isoform 4
NM_001292026.3	NP_001278955.1	tumor protein D53 isoform 5
NM_001300994.3	NP_001287923.1	tumor protein D53 isoform 6
NM_001318903.2	NP_001305832.1	tumor protein D53 isoform 7
NM_001318907.2	NP_001305836.1	tumor protein D53 isoform 5
NM_003287.4	NP_003278.1	tumor protein D53 isoform 1

TPD52L1 Protein Structure

TPD52

0
100
204 a.a.

Protein Preferred Names

Protein Names

tumor protein D53

tumor protein D52 like 1

Related Diseases

Diseases

Alias

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14929	TPD52L1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TPD52L1	MGD	MGI:1298386
Macaca mulatta	TPD52L1	VGNC	VGNC:78632
Felis catus	TPD52L1	VGNC	VGNC:66471
Canis familiaris	TPD52L1	VGNC	VGNC:47734
Rattus norvegicus	TPD52L1	RGD	RGD:1594796
Bos taurus	TPD52L1	VGNC	VGNC:36245

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