TPR - translocated promoter region, nuclear basket protein Gene

Homo sapiens

Gene ID: 7175 | Gene type: protein coding

About TPR

Cytogenetic location: 1q31.1 Genomic coordinates (GRCh38): 1:186,311,652-186,375,253 (from NCBI)

This gene has 9 transcripts (splice variants), 277 orthologues and is associated with 94 phenotypes. Ubiquitous expression in testis (RPKM 29.9), thyroid (RPKM 16.2) and 25 other tissues.

Summary

This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]

TPR Products(1)

mRNA	Protein	Name
NM_003292.3	NP_003283.2	nucleoprotein TPR

TPR Protein Structure

TPR_MLP1_2

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1600
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2363 a.a.

Protein Preferred Names

Protein Names

nucleoprotein TPR

NPC-associated intranuclear protein

Related Diseases

Diseases

Alias

Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome

Jacobs Syndrome	Arthropathy-Camptodactyly Syndrome
Pericarditis-Arthropathy-Camptodactyly Syndrome	Xyy Syndrome
Pac Syndrome	Cacp Syndrome
CACP	Fibrosing Serositis, Familial
Camptodactyly-Arthropathy-Pericarditis Syndrome	Cap Syndrome
47, Xyy Syndrome	47,Xyy Syndrome
Double Y Syndrome	Camptodactyly-Arthropathy-Coxa-Vara-Pericarditis Syndrome
Hypertrophic Synovitis, Congenital Familial	Congenital Familial Hypertrophic Synovitis
Xyy Karyotype	Y Disomy
Yy Syndrome	Familial Fibrosing Serositis
Disomy Y	Double Y
Camptodactyly Arthropathy Coxa Vara Pericarditis Syndrome	Arthropathy Camptodactyly Syndrome
Camptodactyly Arthropathy Pericarditis Syndrome	Pericarditis Arthropathy Camptodactyly Syndrome
Jacob'S Syndrome	47,Xyy
Cdags Syndrome

Differentiated Thyroid Carcinoma

Papillary Or Follicular Thyroid Carcinoma	Well-Differentiated Thyroid Carcinoma
Differentiated Thyroid Gland Carcinoma

Bejel

Njovera	Dichuchwa
Nonvenereal Endemic Syphilis	Endemic Syphilis
Frenga	Nonvenereal Syphilis
Treponemal Infections	Non-Venereal Endemic Syphilis
Siti	Skerljevo
Belesh

Yaws

Frambesia	Frambesia Tropica
Bouba	Frambosie
Polypapilloma Tropicum	Thymosis
Endemic Treponematoses	Treponema Pertenue Infection
Pian	Framboesia
Framboesia Tropica	Castellani
Infection By Treponema Pertenue	Parangi
Framboesioma	Chancre Of Yaws
Primary Framboesia	Initial Lesions Of Yaws
Mother Yaw	Initial Framboesia

Primary Syphilis

Early Symptomatic Syphilis	Early Syphilis, Symptomatic
Symptomatic Early Syphilis

Secondary Syphilis

Syphilis, Secondary

Secondary Syphilis Of Viscera Or Bone

Latent Syphilis

Syphilis, Latent

Late Yaws

Yaws Gummata And Ulcers	Gummata And Ulcers Due To Yaws
Gummata Of Yaws	Gummatous Frambeside
Multiple Papillomata Due To Yaws And Wet Crab Yaws	Nodular Late Yaws
Ulcers Of Yaws

Gummatous Syphilis

Early Yaws

Initial Lesions Of Yaws	Bone And Joint Lesions Due To Yaws
Bone And Joint Yaws Lesion	Chancre Of Yaws
Frambesia, Initial Or Primary	Initial Frambesial Ulcer
Primary Frambesia	Initial Lesion Of Yaws

Early Congenital Syphilis

Occipital Lobe Neoplasm

Neoplasm Of Occipital Lobe	Malignant Neoplasm Of Occipital Lobe
Tumor Of Occipital Lobe

Congenital Syphilis

Syphilis, Congenital	Congenital Syphilis, Unspecified
Mtct Of Syphilis	Mother-To-Child Transmission Of Syphilis
Syphilis Congenital	Hereditary Syphilis
Heredosyphilis

Cardiovascular Syphilis

Syphilis, Cardiovascular

Acute Pericementitis

Acute Periodontitis	Aggressive And Acute Periodontitis
Peridental Infection	Periodontal Infection

Meningovascular Neurosyphilis

Tertiary Syphilis

Late Syphilis	Syphilis, Tertiary
Late Syphilis, Unspecified	Late Tertiary Syphilis

Tertiary Neurosyphilis

Late Neurosyphilis

Late Syphilis Of Central Nervous System Nos

Pulp Degeneration

Degeneration Of Dental Pulp

Parenchymatous Neurosyphilis

Syphilis

Chancre

Syphilitic Chancre

Familial Renal Papillary Carcinoma

Hereditary Papillary Renal Carcinoma

Papillary Renal Cancer Hereditary

Childhood Hepatocellular Carcinoma

Pediatric Hepatocellular Carcinoma	Childhood Carcinoma Of Liver Cell
Childhood Hepatoma	Childhood Liver Cell Carcinoma
Pediatric Carcinoma Of Liver Cell	Pediatric Hepatoma
Pediatric Liver Cell Carcinoma	Childhood-Onset Hcc
Childhood-Onset Hepatocellular Carcinoma	Pediatric Hcc
Childhood Liver Cancer

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma	Hereditary Papillary Renal Cell Carcinoma
Papillary Renal Cell Carcinoma, Sporadic	Papillary Renal Cell Adenocarcinoma
RCCP	RCCP1
Renal Cell Carcinoma, Papillary	Renal Cell Carcinoma, Papillary, 1, Familial And Somatic
Chromophil Carcinoma Of Kidney	Papillary Kidney Carcinoma
Sporadic Papillary Renal Cell Carcinoma	Chromophil Renal Cell Carcinoma
Papillary Renal Carcinoma, Malignant -	Papillary Renal Cell Carcinoma, Bilateral -
Papillary Renal Cell Carcinoma, Familial -	Papillary Renal Cell Carcinoma, Multiple -
Papillary Renal Cell Carcinoma, Sporadic -	Renal Adenocarcinoma
Chromophil Rcc	Hprcc
Renal Cell Carcinoma Papillary	Chromophilic Renal Cell Carcinoma
Prcc	Carcinoma, Renal Cell, Papillary, Type 1
Type 1 Papillary Renal Cell Carcinoma	Renal Cell Carcinoma
Hereditary Papillary Renal Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103241	Ro 90-7501		99.10%	Unkown
HY-125759	3-Phenyltoxoflavin	Inhibitor	99.86%	Unkown
HY-P1896	Hsp70-derived octapeptide		98.01%	Unkown
HY-RS14946	TPR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TPR	VGNC	VGNC:100164
Mus musculus	TPR	MGD	MGI:1922066
Rattus norvegicus	TPR	RGD	RGD:1310664
Felis catus	TPR	VGNC	VGNC:107957
Canis familiaris	TPR	VGNC	VGNC:53807
Others	TPR	NCBI

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