TRHR - thyrotropin releasing hormone receptor Gene

Homo sapiens

Also known as CHNG7; TRH-R

Gene ID: 7201 | Gene type: protein coding

About TRHR

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:109,086,585-109,121,565 (from NCBI)

This gene has 2 transcripts (splice variants), 269 orthologues, 15 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

TRHR Products(1)

mRNA	Protein	Name
NM_003301.7	NP_003292.1	thyrotropin-releasing hormone receptor

TRHR Protein Structure

7tm_1

0
100
200
300
398 a.a.

Protein Preferred Names

Protein Names

thyrotropin-releasing hormone receptor

thyroliberin receptor

Related Diseases

Diseases

Alias

Hypothyroidism, Congenital, Nongoitrous, 7

CHNG7	Thyrotropin-Releasing Hormone Resistance, Generalized
Central Hypothyroidism Due To Trh Receptor Deficiency	Resistance To Thyrotropin-Releasing Hormone Syndrome
Trh Resistance Syndrome	Congenital Nongoitrous Hypothyroidism 7
Hypothyroidism, Congenital, Non-Goitrous, 7	Hypothyroidism, Congenital, Nongoitrous, Type 7

Hypothyroidism

Thyroid Diseases	Thyroid Disease
Thyroid Deficiency	Thyroid Insufficiency
Dysfunction Thyroid	Thyroid Dysfunction

Hypothyroidism, Central, With Testicular Enlargement

X-Linked Central Congenital Hypothyroidism With Late-Onset Testicular Enlargement	CHTE
Hypothyroidism, Central, And Testicular Enlargement	Igsf1 Deficiency Syndrome
X-Linked Central Congenital Hypothyroidism With Late-Onset Macroorchidism	Central Hypothyroidism And Testicular Enlargement
Hypothyroidism, Central, Testicular Enlargement

Acromegaly

Gigantism	Growth Hormone Excess
Pituitary Giant	Somatotroph Adenoma
Growth Hormone-Secreting Pituitary Adenoma

Congenital Hypothyroidism

Cretinism	Neonatal Hypothyroidism
Ch	Cht
Congenital Myxedema	Myxedema, Congenital
Endemic Cretinism	Congenital Iodine-Deficiency Syndrome
Fetal Iodine Deficiency Syndrome	Congenital Iodine-Deficiency Hypothyroidism Nos

Hyperthyroidism

Overactive Thyroid

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0596	Taltirelin	Agonist	99.86%	Unkown
HY-B0596A	Taltirelin acetate	Agonist	98.77%	Unkown

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0596S	Taltirelin-13C,d3		/	Unkown
HY-RS15013	TRHR Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRHR	VGNC	VGNC:36306
Mus musculus	TRHR	MGD	MGI:98824
Felis catus	TRHR	VGNC	VGNC:66526
Rattus norvegicus	TRHR	RGD	RGD:3904
Macaca mulatta	TRHR	VGNC	VGNC:78645
Canis familiaris	TRHR	VGNC	VGNC:47799

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