2. Gene
  3. TSN - translin Gene

TSN - translin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C3PO; RCHF1; TBRBP; TRSLN; BCLF-1; REHF-1

Gene ID: 7247 | Gene type: protein coding

About TSN

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:121,755,651-121,767,853 (from NCBI)

This gene has 12 transcripts (splice variants), 208 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 26.5), brain (RPKM 20.8) and 25 other tissues.

Summary

This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. This protein encoded by this gene, when complexed with translin-associated protein X, also forms a Mg ion-dependent endoribonuclease that promotes RNA-induced silencing complex (RISC) activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

TSN Products(2)

mRNA Protein Name
NM_001261401.2 NP_001248330.1 translin isoform 2
NM_004622.3 NP_004613.1 translin isoform 1

TSN Protein Structure

Translin

Translin: Translin family (18 - 216)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

translin

component 3 of promoter of RISC

Related Diseases

Diseases Alias
Liposarcoma

Lipomatous Cancer
Dysgerminoma
Sotos Syndrome

Cerebral Gigantism

SOTOS

Chromosome 5q35 Deletion Syndrome

Sotos Syndrome 1, Formerly

Sotos1, Formerly

Distinctive Facial Appearance, Overgrowth In Childhood, And Learning Disabilities Or Delayed Development

Sotos Sequence

Sotos' Syndrome

Sotos1

Sotos Syndrome 1
Chromosome 1p36 Deletion Syndrome

1p36 Deletion Syndrome

Deletion 1p36

Monosomy 1p36

Subtelomeric 1p36 Deletion

Monosomy 1p36 Syndrome

Distal Monosomy 1p36

Del(1)(P36)

Deletion 1pter

Monosomy 1pter
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15154 TSN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TSN VGNC VGNC:47907
Bos taurus TSN VGNC VGNC:36422
Macaca mulatta TSN VGNC VGNC:78663
Felis catus TSN VGNC VGNC:82547
Rattus norvegicus TSN RGD RGD:621107
Mus musculus TSN MGD MGI:109263
Others TSN NCBI