2. Gene
  3. Sting1 - stimulator of interferon response cGAMP interactor 1 Gene

Sting1 - stimulator of interferon response cGAMP interactor 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as ERIS; MPYS; Mita; STING; Tmem173; STING-beta; 2610307O08Rik

Gene ID: 72512 | Gene type: protein coding

About Sting1

Chromosome 18: 35,866,732-35,873,607 reverse strand.GRCm39:CM001011.3

This gene has 10 transcripts (splice variants), 184 orthologues and is associated with 35 phenotypes. Broad expression in spleen adult (RPKM 3.3), mammary gland adult (RPKM 29.1) and 2 other tissues.

Summary

Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; macroautophagy; and positive regulation of interferon-beta production. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including autophagosome; perinuclear region of cytoplasm; and peroxisome. Is expressed in ductus deferens; epididymis; ileum; and prostate gland. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2022]

Sting1 Products(3)

mRNA Protein Name
NM_028261.1 NP_082537.1 stimulator of interferon genes protein isoform 1
NM_001289592.1 NP_001276521.1 stimulator of interferon genes protein isoform 3
NM_001289591.1 NP_001276520.1 stimulator of interferon genes protein isoform 2

Sting1 Protein Structure

TMEM173

TMEM173: pfam15009 (43 - 335)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
Protein Preferred Names Protein Names

stimulator of interferon genes protein

endoplasmic reticulum interferon stimulator

mediator of IRF3 activation

mitochondrial mediator of IRF3 activation

stimulator of interferon protein

transmembrane protein 173

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-112906 C-176 Inhibitor 99.45% Unkown
HY-138683 STING-IN-3 Inhibitor 99.86% Unkown
HY-114399 STING ligand-1 99.79% Unkown
HY-12885C ADU-S100 enantiomer ammonium salt 98.82% Unkown
HY-RS13916 STING1 Human Pre-designed siRNA Set A / Unkown
HY-RS13917 Sting1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS13918 Sting1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sting1 NCBI NCBI:340061