2. Gene
  3. UBE2B - ubiquitin conjugating enzyme E2 B Gene

UBE2B - ubiquitin conjugating enzyme E2 B Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HR6B; UBC2; HHR6B; RAD6B; E2-17kDa

Gene ID: 7320 | Gene type: protein coding

About UBE2B

Cytogenetic location: 5q31.1 Genomic coordinates (GRCh38): 5:134,371,569-134,392,108 (from NCBI)

This gene has 8 transcripts (splice variants), 223 orthologues and 24 paralogues. Ubiquitous expression in adrenal (RPKM 31.0), heart (RPKM 26.8) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this Enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq, Jul 2008]

UBE2B Products(1)

mRNA Protein Name
NM_003337.4 NP_003328.1 ubiquitin-conjugating enzyme E2 B

UBE2B Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (8 - 143)

  • 0
  • 100
  • 152 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 B

E2 protein

Recombinant UBE2B Proteins

Cat. No. Product Name Accession Purity
HY-P71398 UBE2B Protein, Human (HEK293, His) P63146 (M1-S152) ≥95%

Related Diseases

Diseases Alias
Halothane Hepatitis

Hepatitis Halothane
Johanson-Blizzard Syndrome

JBS

Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness

Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness

Johanson Blizzard Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15337 UBE2B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBE2B VGNC VGNC:78692
Canis familiaris UBE2B VGNC VGNC:56072
Bos taurus UBE2B VGNC VGNC:36577
Rattus norvegicus UBE2B RGD RGD:708345
Mus musculus UBE2B MGD MGI:102944
Felis catus UBE2B VGNC VGNC:102356
Others UBE2B NCBI