2. Gene
  3. UBE2E2 - ubiquitin conjugating enzyme E2 E2 Gene

UBE2E2 - ubiquitin conjugating enzyme E2 E2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UBCH8

Gene ID: 7325 | Gene type: protein coding

About UBE2E2

Cytogenetic location: 3p24.3 Genomic coordinates (GRCh38): 3:23,203,098-23,591,925 (from NCBI)

This gene has 7 transcripts (splice variants), 139 orthologues and 12 paralogues. Ubiquitous expression in brain (RPKM 1.5), fat (RPKM 1.2) and 25 other tissues.

Summary

Enables ISG15 transferase activity and ubiquitin conjugating Enzyme activity. Involved in protein modification by small protein conjugation. Acts upstream of or within cellular response to DNA damage stimulus and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

UBE2E2 Products(5)

mRNA Protein Name
NM_001370225.1 NP_001357154.1 ubiquitin-conjugating enzyme E2 E2 isoform 1
NM_001370226.1 NP_001357155.1 ubiquitin-conjugating enzyme E2 E2 isoform 2
NM_001370227.1 NP_001357156.1 ubiquitin-conjugating enzyme E2 E2 isoform 3
NM_001370228.1 NP_001357157.1 ubiquitin-conjugating enzyme E2 E2 isoform 3
NM_152653.4 NP_689866.1 ubiquitin-conjugating enzyme E2 E2 isoform 1

UBE2E2 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (59 - 195)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 E2

E2 ubiquitin-conjugating enzyme E2

Related Diseases

Diseases Alias
Immunodeficiency 38 With Basal Ganglia Calcification

Mendelian Susceptibility To Mycobacterial Diseases Due To Complete Isg15 Deficiency

IMD38

Immunodeficiency 38, Mycobacteriosis, Autosomal Recessive

Immunodeficiency 38

Isg15 Deficiency, Autosomal Recessive

Immunodeficiency 38, With Basal Ganglia Calcification

Autosomal Recessive Isg15 Deficiency

Msmd Due To Complete Isg15 Deficiency

Immunodeficiency, Type 38
Intracranial Arteriosclerosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15343 UBE2E2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta UBE2E2 VGNC VGNC:78415
Rattus norvegicus UBE2E2 RGD RGD:1305644
Mus musculus UBE2E2 MGD MGI:2384997
Bos taurus UBE2E2 VGNC VGNC:107010
Others UBE2E2 NCBI