SLC35A2 - solute carrier family 35 member A2 Gene

Homo sapiens

Also known as UGT; CDGX; UGAT; UGT1; UGT2; UGTL; CDG2M; UGALT; UDP-Gal-Tr

Gene ID: 7355 | Gene type: protein coding

About SLC35A2

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,903,183-48,911,958 (from NCBI)

This gene has 18 transcripts (splice variants), 186 orthologues, 4 paralogues and is associated with 4 phenotypes. Ubiquitous expression in colon (RPKM 9.3), stomach (RPKM 6.6) and 25 other tissues.

Summary

This gene encodes a member of the nucleotide-sugar transporter family. The encoded protein is a multi-pass membrane protein. It transports UDP-galactose from the cytosol into Golgi vesicles, where it serves as a glycosyl donor for the generation of glycans. Mutations in this gene cause congenital disorder of glycosylation type IIm (CDG2M). Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2014]

SLC35A2 Products(8)

mRNA	Protein	Name
NM_001032289.3	NP_001027460.1	UDP-galactose translocator isoform b
NM_001042498.3	NP_001035963.1	UDP-galactose translocator isoform c
NM_001282647.2	NP_001269576.1	UDP-galactose translocator isoform d
NM_001282648.2	NP_001269577.1	UDP-galactose translocator isoform e
NM_001282649.2	NP_001269578.1	UDP-galactose translocator isoform f
NM_001282650.2	NP_001269579.1	UDP-galactose translocator isoform g
NM_001282651.2	NP_001269580.1	UDP-galactose translocator isoform h
NM_005660.3	NP_005651.1	UDP-galactose translocator isoform a

SLC35A2 Protein Structure

Nuc_sug_transp

0
100
200
300
396 a.a.

Protein Preferred Names

Protein Names

UDP-galactose translocator

solute carrier family 35 (UDP-galactose transporter), member 2

Related Diseases

Diseases

Alias

Congenital Disorder Of Glycosylation, Type Iim

CDG2M	Congenital Disorder Of Glycosylation Type Iim
Slc35a2-Cdg	Epileptic Encephalopathy, Early Infantile, 22
Cdg-Iim	Cdg Iim
Cdgiim	Developmental And Epileptic Encephalopathy 22
Eiee22	Congenital Disorder Of Glycosylation Type 2m
Cdg Syndrome Type Iim	Dee22
Slc35a2-Congenital Disorder Of Glycosylation	Epileptic Encephalopathy, Early Infantile, 22
Eiee22	Congenital Disorder Of Glycosylation 2m
Congenital Disorder Of Glycosylation X-Linked	Glycosylation, Congenital Disorder Of, Type Iim

Isolated Focal Cortical Dysplasia Type Ia

Fcd Type Ia

Hepatitis D

Delta Hepatitis	Hepatitis Delta
Hdv	Hepatitis D Virus
Hepatitis D Infection

Epilepsy, Idiopathic Generalized 10

EIG10	Epilepsy, Idiopathic Generalized, Susceptibility To, 10
Generalized Epilepsy With Febrile Seizures Plus, Type 5	Epilepsy, Juvenile Myoclonic, Susceptibility To
Epilepsy, Idiopathic Generalized, 10	Idiopathic Generalized Epilepsy 10
Epilepsy, Juvenile Myoclonic 7	Generalized Epilepsy With Febrile Seizures Plus Type 5
Generalized Epilepsy With Febrile Seizures Plus, Type 5, Susceptibility To	Epilepsy, Juvenile Myoclonic
Susceptibility To Idiopathic Generalized Epilepsy 10	Generalized Epilepsy With Febrile Seizures Plus 5
GEFS+5	Gefs+ Type 5
Gefsp5	Juvenile Myoclonic Epilepsy 7
EJM7	Susceptibility To Juvenile Myoclonic Epilepsy 7
Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 10	Myoclonic Epilepsy, Juvenile

Congenital Disorder Of Glycosylation, Type Iin

CDG2N	Slc39a8-Cdg
Cdg Iin	Congenital Disorder Of Glycosylation Type Iin
Cdgiin	Carbohydrate Deficient Glycoprotein Syndrome Type Iin
Cdg Syndrome Type Iin	Congenital Disorder Of Glycosylation Type 2n
Cdg-Iin	Cdgiidn
Slc39a8 Deficiency	Congenital Disorder Of Glycosylation 2n
Glycosylation, Congenital Disorder Of, Type Iin

Immunodeficiency 47

Congenital Disorder Of Glycosylation Type Ii	CDG2E
Congenital Disorder Of Glycosylation Type Iie	IMD47
Cdg2s	Cdg Iis
Cdgiis	Immunodeficiency And Hepatopathy With Or Without Neurologic Features
Congenital Disorder Of Glycosylation, Type Ii	CDG1I
Congenital Disorder Of Glycosylation, Type Iie	Cdg Iie
Congenital Disorder Of Glycosylation Type 2e	Congenital Disorder Of Glycosylation, Type Iis
Cdg Ii	Cdgii
Cdgiie	Carbohydrate Deficient Glycoprotein Syndrome Type Iie
Cdg Syndrome Type Iie	Congenital Disorder Of Glycosylation Ii
Congenital Disorder Of Glycosylation 1i	Cdg-Iie
Alg2-Cdg	Cdg-Ii
Glycosylation, Congenital Disorder Of, Type Ii	Cdgiide
Congenital Disorder Of Glycosylation Type Iis	Cog7-Cdg
Cdg Syndrome Type Ii	Carbohydrate Deficient Glycoprotein Syndrome Type Ii
Congenital Disorder Of Glycosylation Type 1i	Mannosyltransferase 2 Deficiency
Congenital Disorder Of Glycosylation 2e	Congenital Disorder Of Glycosylation 2s
Congenital Disorders Of Glycosylation Type Ii	Glycosylation, Congenital Disorder Of, Type Iie
Immunodeficiency, Type 47	Congenital Disorder Of Glycosylation Type 2a

Congenital Disorder Of Glycosylation, Type Iik

CDG2K	Congenital Disorder Of Glycosylation Type Iik
Cdg Iik	Cdgiik
Carbohydrate Deficient Glycoprotein Syndrome Type Iik	Cdg Syndrome Type Iik
Congenital Disorder Of Glycosylation Type 2k	Tmem165-Cdg
Cdg-Iik	Cdgiidk
Congenital Disorder Of Glycosylation 2k	Glycosylation, Congenital Disorder Of, Type Iik

Urogenital Tuberculosis

Tuberculosis, Urogenital

Genitourinary Tuberculosis

Epilepsy, Idiopathic Generalized 11

Epilepsy, Idiopathic Generalized, Susceptibility To, 11	EIG11
Epilepsy, Juvenile Absence 2	Epilepsy, Juvenile Myoclonic 8
Idiopathic Generalized Epilepsy 11	Epilepsy, Juvenile Absence, Susceptibility To, 2
Epilepsy, Juvenile Myoclonic, Susceptibility To, 8	Susceptibility To Idiopathic Generalized Epilepsy 11
Juvenile Absence Epilepsy 2	JAE2
Eja2	Susceptibility To Juvenile Absence Epilepsy 2
Juvenile Myoclonic Epilepsy 8	EJM8
Susceptibility To Juvenile Myoclonic Epilepsy 8	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 11

Bladder Tuberculosis

Tuberculous Cystitis

Tuberculosis Of Bladder

Kernicterus

Bilirubin Encephalopathy	Hyperbilirubinemic Encephalopathy
Kernicterus Spectrum Disorder

Crigler-Najjar Syndrome, Type I

Crigler-Najjar Syndrome	Crigler-Najjar Syndrome Type 1
Bilirubin Udp Glucuronyl Transferase Deficiency	Crigler Najjar Syndrome
Crigler Najjar Syndrome, Type 1	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency
Bilirubin-Ugt Deficiency	Hyperbilirubinemia, Crigler-Najjar Type I
Hblrcn1	Familial Nonhemolytic Unconjugated Hyperbilirubinemia
Hereditary Unconjugated Hyperbilirubinemia	Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1
Bilirubin-Ugt Deficiency Type 1	Crigler-Najjar Syndrome 1
CN1	Cn-I
Crigler-Najjar Syndrome Type I	Hereditary Unconjugated Hyperbilirubinaemia
Ugt Deficiency	Bilirubin Glucuronosyltransferase Deficiency
Crigler-Najjar Disease Or Syndrome	Deficiency Of Glucuronosyltransferase
Glucuronyl Transferase Deficiency	Glucuronyltransferase Deficiency
Udp Glucuronyl Transferase Deficiency	Cns - [Crigler-Najjar Syndrome]
Congenital Familial Nonhemolytic Jaundice

Gilbert Syndrome

Gilbert Disease	Gilbert'S Disease
Gilbert'S Syndrome	Cholemia, Familial
Familial Nonhemolytic Jaundice	Meulengracht Syndrome
Gilbert Syndrome, Susceptibility To	Hyperbilirubinemia, Gilbert Type
Hblrg	Hyperbilirubinemia, Arias Type
Hyperbilirubinemia I	Constitutional Hyperbilirubinemia
Gilbert-Meulengracht Syndrome	Hereditary Nonhemolytic Jaundice
Hyperbilirubinemia Arias Type	Hyperbilirubinemia Type 1
Constitutional Liver Dysfunction	Gilbert-Lereboullet Syndrome
Hyperbilirubinemia 1	Unconjugated Benign Bilirubinemia
GILBS	Gilberts Syndrome
Familial Nonhaemolytic Jaundice	Constitutional Hyperbilirubinaemia
Hereditary Nonhaemolytic Bilirubinaemia	Familial Nonhaemolytic Bilirubinaemia
Idiopathic Hyperbilirubinaemia	Icterus Intermittens Juvenilis
Chronic Intermittent Juvenile Jaundice	Low-Grade Chronic Hyperbilirubinaemia Syndrome
Benign Unconjugated Bilirubinaemia Syndrome	Hereditary Nonhaemolytic Jaundice
Idiopathic Unconjugated Hyperbilirubinaemia	Gilbert--Lereboullet Syndrome
Constitutional Hepatic Dysfunction	Meulengracht Icterus
Cholaemia Familiaris Simplex	Familial Cholaemia
Congenital Familial Cholaemia	Physiologic Cholaemia
Hyperbilirubinaemia Type 1	Gilbert Cholaemia

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Congenital Disorder Of Glycosylation, Type Iif

CDG2F	Congenital Disorder Of Glycosylation Type Iif
Cdg Iif	Cdgiif
Carbohydrate Deficient Glycoprotein Syndrome Type Iif	Cmp-Sialic Acid Transporter Deficiency
Slc35a1-Cdg	Cdg-Iif
Cdgiidf	Cdg Syndrome Type Iif
Congenital Disorder Of Glycosylation Type 2f	Congenital Disorder Of Glycosylation 2f
Glycosylation, Congenital Disorder Of, Type Iif

Bilirubin Metabolic Disorder

Hyperbilirubinemia	Hereditary Hyperbilirubinemia
Hyperbilirubinemia, Hereditary	Hyperbilirubinaemia

Neonatal Abstinence Syndrome

Drug Withdrawal Syndrome In Newborn

Schneckenbecken Dysplasia

SHNKND	Chondrodysplasia, Lethal Neonatal, With Snail-Like Pelvis
Chondrodysplasia Lethal Neonatal With Snail Like Pelvis	Chondrodysplasia With Snail-Like Pelvis
Slc35d1-Cdg	Dysplasia, Schneckenbecken

Congenital Disorder Of Glycosylation, Type In

Congenital Disorder Of Glycosylation	CDG1N
Congenital Disorders Of Glycosylation	Cdg In
Cdgin	Congenital Disorder Of Glycosylation 1n
Carbohydrate-Deficient Glycoprotein Syndrome	Cdg
Rft1-Cdg	Cdg-In
Congenital Disorder Of Glycosylation Type In	Carbohydrate Deficient Glycoprotein Syndrome
Cdg Syndrome	Congenital Disorder Of Glycosylation In
Carbohydrate-Deficient Glycoprotein Syndromes	Cdg Syndrome Type In
Carbohydrate Deficient Glycoprotein Syndrome Type In	Congenital Disorder Of Glycosylation Type 1n
Man5glcnac2-Pp-Dol Flippase Deficiency	Glycosylation, Congenital Disorder Of
Glycosylation, Congenital Disorder Of, Type In

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS13196	SLC35A2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS13199	SLC35B2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS13202	SLC35D2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS13206	SLC35F2 Human Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC35A2	MGD	MGI:1345297
Rattus norvegicus	SLC35A2	RGD	RGD:2293497
Bos taurus	SLC35A2	VGNC	VGNC:34820
Canis familiaris	SLC35A2	VGNC	VGNC:46361
Felis catus	SLC35A2	VGNC	VGNC:65320
Macaca mulatta	SLC35A2	VGNC	VGNC:77460
Others	SLC35A2	NCBI

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