2. Gene
  3. ZAN - zonadhesin Gene

ZAN - zonadhesin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 7455 | Gene type: protein coding

About ZAN

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,733,595-100,797,797 (from NCBI)

This gene has 8 transcripts (splice variants), 147 orthologues and 19 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a protein that functions in the species specificity of sperm adhesion to the egg zona pellucida. The encoded protein is located in the acrosome and may be involved in signaling or gamete recognition. An allelic polymorphism in this gene results in both functional and frameshifted alleles; the reference genome represents the functional allele. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2015]

ZAN Products(2)

mRNA Protein Name
NM_003386.3 NP_003377.2 zonadhesin isoform 3 precursor
NM_173059.3 NP_775082.2 zonadhesin isoform 6 precursor

ZAN Protein Structure

MAM

MAM: MAM domain, meprin/A5/mu (41 - 203)

MAM

MAM: MAM domain, meprin/A5/mu (211 - 367)

MAM

MAM: MAM domain, meprin/A5/mu (373 - 535)

TIL

TIL: Trypsin Inhibitor like cysteine rich domain (1044 - 1093)

TILa

TILa: TILa domain (1094 - 1148)

VWD

VWD: von Willebrand factor type D domain (1156 - 1307)

C8

C8: C8 domain (1353 - 1423)

TIL

TIL: Trypsin Inhibitor like cysteine rich domain (1426 - 1479)

TILa

TILa: TILa domain (1480 - 1535)

VWD

VWD: von Willebrand factor type D domain (1542 - 1695)

C8

C8: C8 domain (1738 - 1809)

TIL

TIL: Trypsin Inhibitor like cysteine rich domain (1812 - 1867)

TILa

TILa: TILa domain (1868 - 1920)

VWD

VWD: von Willebrand factor type D domain (1930 - 2084)

C8

C8: C8 domain (2134 - 2207)

TIL

TIL: Trypsin Inhibitor like cysteine rich domain (2210 - 2266)

TILa

TILa: TILa domain (2267 - 2322)

VWD

VWD: von Willebrand factor type D domain (2330 - 2483)

C8

C8: C8 domain (2541 - 2617)

EGF

EGF: EGF-like domain (2620 - 2648)

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  • 2720 a.a.
Protein Preferred Names Protein Names

zonadhesin

Related Diseases

Diseases Alias
Granulomatous Orchitis

Non-Specific Granulomatous Orchitis
Deafness, Autosomal Recessive 21

DFNB21

Autosomal Recessive Nonsyndromic Deafness 21

Autosomal Recessive Deafness 21

Deafness, Autosomal Recessive, 21

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 21

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 21

Deafness, Autosomal Recessive, Type 21
Von Willebrand Disease, Type 2

Von Willebrand Disease Type 2m

Von Willebrand Disease Type 2

Von Willebrand Disease Type 2a

Von Willebrand Disease Type 2b

Von Willebrand Disease Type 2n

VWD2

Von Willebrand'S Disease 2

Von Willebrand Disease Type Ii

Von Willebrand Disease, Type Ii

Vwd, Type 2

Von Willebrand Disease, Types 2a, 2b, 2m, And 2n

Vwd Type 2

Von Willebrand Disease 2

Von Willebrand Disease Normandy Variant

Von Willebrand Disease Type 2 Malmo

Von Willebrand Disease Type I New York

Von Willebrand Factor Deficiency Type 2

Vwd2a

Vwd2b

Vwd2m

Vwd2n

Von Willebrand Disease, Type 2a, 2b, 2m, And 2n

Von Willebrand Disease, Type 2a

Von Willebrand Disease, Type 2b

Von Willebrand Disease, Type 2n
Deafness, Autosomal Dominant 13

DFNA13

Autosomal Dominant Nonsyndromic Deafness 13

Autosomal Dominant Deafness 13

Deafness, Autosomal Dominant, 13

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 13

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 13

Deafness, Autosomal Dominant, Type 13
Deafness, Autosomal Dominant 44

DFNA44

Autosomal Dominant Nonsyndromic Deafness 44

Autosomal Dominant Deafness 44

Deafness, Autosomal Dominant, 44

Deafness, Autosomal Dominant, Type 44
Von Willebrand Disease, Type 1

Von Willebrand Disease Type 1

VWD1

Von Willebrand'S Disease 1

Von Willebrand Disease Type I

Von Willebrand Disease, Type I

Vwd, Type 1

Vwd Type 1

Von Willebrand Disease 1

Von Willebrand Factor Deficiency Type 1

Von Willebrand Disease, Type 1, Susceptibility To
Von Willebrand Disease, Type 3

Von Willebrand Disease Type 3

VWD3

Von Willebrand'S Disease 3

Von Willebrand Disease Type Iii

Von Willebrand Disease, Type Iii

Vwd, Type 3

Vwd Type 3

Von Willebrand Disease 3

Von Willebrand Disease Recessive Form

Von Willebrand Factor Deficiency Type 3
Orchitis

Inflammation Of Testis

Orchititis

Mumps Orchitis
Tick Paralysis
Epididymo-Orchitis
Deafness, Autosomal Dominant 10

DFNA10

Autosomal Dominant Nonsyndromic Deafness 10

Autosomal Dominant Deafness 10

Deafness, Autosomal Dominant, 10

Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 10

Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 10

Deafness, Autosomal Dominant, Type 10
Autosomal Recessive Nonsyndromic Deafness

Deafness, Autosomal Recessive, Nonsyndromic
Autosomal Dominant Nonsyndromic Deafness

Autosomal Dominant Deafness
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15950 ZAN Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ZAN RGD RGD:1305044
Macaca mulatta ZAN VGNC VGNC:81797
Bos taurus ZAN VGNC VGNC:99806
Felis catus ZAN VGNC VGNC:80703
Mus musculus ZAN MGD MGI:106656
Others ZAN NCBI