YES1 - YES proto-oncogene 1, Src family tyrosine kinase Gene

Homo sapiens

Also known as Yes; c-yes; HsT441; P61-YES

Gene ID: 7525 | Gene type: protein coding

About YES1

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:721,588-812,753 (from NCBI)

This gene has 5 transcripts (splice variants), 261 orthologues and 32 paralogues. Ubiquitous expression in placenta (RPKM 22.4), fat (RPKM 16.6) and 25 other tissues.

Summary

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the Src family of proteins. This gene lies in close proximity to Thymidylate Synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

YES1 Products(1)

mRNA	Protein	Name
NM_005433.4	NP_005424.1	tyrosine-protein kinase Yes

YES1 Protein Structure

SH3_1

SH2

Pkinase_Tyr

0
100
200
300
400
500
543 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein kinase Yes

YES1 proto-oncogene, Src family tyrosine kinase

Recombinant YES1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73486	YES1 Protein, Human (sf9, His-GST)	P07947 (G2-L543)	≥95%

Related Diseases

Diseases

Alias

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Co-Trimoxazole Allergy

Bactrim Allergy	Cotrimoxazol Allergy
Tmp/Smx Allergy	Trimethoprim/Sulfamethoxazole Allergy

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Thrombocytopenia

Low Platelet Count	Low Platelets
Decreased Platelets	Platelet Dysfunction Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.00%	Unkown
HY-135299	CH6953755	Inhibitor	98.03%	Unkown
HY-145373	BMS-986143	Inhibitor	/	Unkown
HY-E70293	N-Acetylgalactosaminyltransferase 12		/	Unkown
HY-RS15922	YES1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	YES1	RGD	RGD:3977
Bos taurus	YES1	VGNC	VGNC:37022
Canis familiaris	YES1	VGNC	VGNC:48484
Mus musculus	YES1	MGD	MGI:99147
Macaca mulatta	YES1	VGNC	VGNC:78817
Felis catus	YES1	VGNC	VGNC:67136
Others	YES1	NCBI

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