SLC30A4 - solute carrier family 30 member 4 Gene

Homo sapiens

Also known as ZNT4; znT-4

Gene ID: 7782 | Gene type: protein coding

About SLC30A4

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,479,606-45,522,755 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 8 paralogues. Biased expression in prostate (RPKM 22.0), testis (RPKM 4.0) and 12 other tissues.

Summary

Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).[supplied by OMIM, Mar 2008]

SLC30A4 Products(2)

mRNA	Protein	Name
NM_001321036.2	NP_001307965.1	zinc transporter 4 isoform 2
NM_013309.6	NP_037441.2	zinc transporter 4 isoform 1

SLC30A4 Protein Structure

Cation_efflux

0
100
200
300
400
429 a.a.

Protein Preferred Names

Protein Names

zinc transporter 4

solute carrier family 30 (zinc transporter), member 4

Related Diseases

Diseases

Alias

Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica	AEZ
Enteropathica	Brandt Syndrome
Ae	Acrodermatitis Enteropathica Zinc Deficiency Type
Danbolt-Cross Syndrome	Acrodermatitis Enteropathica, Zinc Deficiency Type
Inherited Zinc Deficiency	Acrodermatitis Enteropathica, Zinc Deficiency
Danbolt-Closs Syndrome	Primary Zinc Malabsorption Syndrome

Acrodermatitis

Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like	Scd-Eds
EDSSPD3	Ehlers-Danlos Syndrome Spondylodysplastic Type 3
Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type	Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome
Slc39a13-Related Speds	Slc39a13-Related Spondylodysplastic Eds
Spondylocheirodysplastic Ehlers-Danlos Syndrome	Speds-Slc39a13
Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia	Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3

Mucinous Stomach Adenocarcinoma

Mucinous Adenocarcinoma Of The Stomach

Mucinous Gastric Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13182	SLC30A4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC30A4	VGNC	VGNC:49968
Felis catus	SLC30A4	VGNC	VGNC:65310
Mus musculus	SLC30A4	MGD	MGI:1345282
Rattus norvegicus	SLC30A4	RGD	RGD:619750
Canis familiaris	SLC30A4	VGNC	VGNC:46349
Macaca mulatta	SLC30A4	VGNC	VGNC:77454
Others	SLC30A4	NCBI

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