DNALI1 - dynein axonemal light intermediate chain 1 Gene

Homo sapiens

Also known as P28; hp28; dJ423B22.5

Gene ID: 7802 | Gene type: protein coding

About DNALI1

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:37,556,940-37,566,857 (from NCBI)

This gene has 6 transcripts (splice variants) and 232 orthologues. Broad expression in testis (RPKM 23.5), ovary (RPKM 8.6) and 16 other tissues.

Summary

This gene is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects. [provided by RefSeq, Jul 2008]

DNALI1 Products(1)

mRNA	Protein	Name
NM_003462.5	NP_003453.3	axonemal dynein light intermediate polypeptide 1

DNALI1 Protein Structure

Ax_dynein_light

0
100
200
280 a.a.

Protein Preferred Names

Protein Names

axonemal dynein light intermediate polypeptide 1

dJ423B22.5 (axonemal dynein light chain (hp28))

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 25

Primary Ciliary Dyskinesia 25	CILD25
Primary Ciliary Dyskinesia 25 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 25, With Or Without Situs Inversus
Dyskinesia, Ciliary, Primary, Type 25

Ciliary Dyskinesia, Primary, 2

Primary Ciliary Dyskinesia 2	CILD2
Primary Ciliary Dyskinesia 2 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 2, With Or Without Situs Inversus
Ics2	Immotile Cilia Syndrome 2
Dyskinesia, Ciliary, Primary, 2

Ethmoid Sinusitis

Ethmoidal Sinusitis

Ethmoiditis

Ciliary Dyskinesia, Primary, 1

CILD1	Pcd
Primary Ciliary Dyskinesia 1	Kartagener Syndrome
Ciliary Dyskinesia, Primary, 1, With Or Without Situs Inversus	Immotile Cilia Syndrome
Ics	Polynesian Bronchiectasis
Primary Ciliary Dyskinesia 1 With Or Without Situs Inversus	Ics1
Immotile Cilia Syndrome 1	Primary Ciliary Dyskinesia
KTGS	Dextrocardia-Bronchiectasis-Sinusitis Syndrome
Immotile Cilia Syndrome Kartagener Type	Primary Ciliary Dyskinesia Kartagener Type
Siewert Syndrome	Immotile Cilia
Dyskinesia, Ciliary, Primary, Type 1	Ciliary Motility Disorders

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Sphenoid Sinusitis

Sphenoidal Sinusitis

Maxillary Sinusitis

Kartagener Syndrome

Kartagener'S Syndrome

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03893	DNALI1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DNALI1	RGD	RGD:1309260
Bos taurus	DNALI1	VGNC	VGNC:28131
Canis familiaris	DNALI1	VGNC	VGNC:54297
Mus musculus	DNALI1	MGD	MGI:1922813
Macaca mulatta	DNALI1	VGNC	VGNC:71836
Felis catus	DNALI1	VGNC	VGNC:61550

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