DHX58 - DExH-box helicase 58 Gene

Homo sapiens

Also known as LGP2; RLR-3; D11LGP2; D11lgp2e

Gene ID: 79132 | Gene type: protein coding

About DHX58

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:42,101,411-42,112,714 (from NCBI)

This gene has 8 transcripts (splice variants), 242 orthologues and 2 paralogues. Ubiquitous expression in spleen (RPKM 10.6), testis (RPKM 8.8) and 25 other tissues.

Summary

Enables double-stranded RNA binding activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in negative regulation of defense response and negative regulation of type I interferon production. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

DHX58 Products(1)

mRNA	Protein	Name
NM_024119.3	NP_077024.2	ATP-dependent RNA helicase DHX58

DHX58 Protein Structure

ResIII

Helicase_C

RIG-I_C-RD

0
200
400
600
678 a.a.

Protein Preferred Names

Protein Names

ATP-dependent RNA helicase DHX58

probable ATP-dependent RNA helicase DHX58

ATP-dependent helicase LGP2

Related Diseases

Diseases

Alias

Measles

Rubeola	Morbilli
Measles Nos	Koplik Spots

Rabies

Lyssa	Hydrophobia
St Hubert Disease

Ileum Cancer

Ileal Neoplasm	Malignant Neoplasm Of Ileum
Ileal Cancer	Ileal Neoplasms

Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome	Ophthalmoacromelic Syndrome
OAS	MLA
Anophthalmia-Syndactyly	Anophthalmia-Syndactyly Syndrome
Anophthalmos With Limb Anomalies	Anophthalmia Waardenburg Syndrome
Anophthalmos-Syndactyly	Ophthalmo-Acromelic Syndrome
Anophthalmia-Waardenburg Syndrome	Anophthalmos-Limb Anomalies Syndrome
Syndactyly-Anophthalmos Syndrome	Microphthalmia, With Limb Anomalies

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Keratitis, Hereditary

Keratitis	Autosomal Dominant Keratitis
Hereditary Keratitis	Dominantly Inherited Keratitis
Keratitis Hereditary	KERH

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03759	DHX58 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	DHX58	VGNC	VGNC:39951
Rattus norvegicus	DHX58	RGD	RGD:1310093
Macaca mulatta	DHX58	VGNC	VGNC:71815
Mus musculus	DHX58	MGD	MGI:1931560
Felis catus	DHX58	VGNC	VGNC:61486
Bos taurus	DHX58	VGNC	VGNC:28058
Others	DHX58	NCBI

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