PLEKHF1 - pleckstrin homology and FYVE domain containing 1 Gene

Homo sapiens

Also known as APPD; LAPF; PHAFIN1; ZFYVE15

Gene ID: 79156 | Gene type: protein coding

About PLEKHF1

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,665,461-29,675,477 (from NCBI)

This gene has 4 transcripts (splice variants), 234 orthologues and 13 paralogues. Ubiquitous expression in fat (RPKM 4.0), spleen (RPKM 2.2) and 24 other tissues.

Summary

Enables phosphatidylinositol-3-phosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylinositol-5-phosphate binding activity. Involved in endosome organization; positive regulation of autophagy; and protein localization to plasma membrane. Located in lysosome. Colocalizes with endosome. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHF1 Products(1)

mRNA	Protein	Name
NM_024310.5	NP_077286.3	pleckstrin homology domain-containing family F member 1

PLEKHF1 Protein Structure

FYVE

0
100
200
279 a.a.

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family F member 1

PH and FYVE domain-containing protein 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10687	PLEKHF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLEKHF1	MGD	MGI:1919537
Macaca mulatta	PLEKHF1	VGNC	VGNC:76085
Felis catus	PLEKHF1	VGNC	VGNC:64224
Bos taurus	PLEKHF1	VGNC	VGNC:33012
Canis familiaris	PLEKHF1	VGNC	VGNC:44675
Rattus norvegicus	PLEKHF1	RGD	RGD:1310544

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