KREMEN2 - kringle containing transmembrane protein 2 Gene

Homo sapiens

Also known as KRM2

Gene ID: 79412 | Gene type: protein coding

About KREMEN2

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,964,275-2,968,380 (from NCBI)

This gene has 6 transcripts (splice variants), 99 orthologues and 1 paralogue. Biased expression in skin (RPKM 2.2), brain (RPKM 0.7) and 7 other tissues.

Summary

This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (Wnt)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the Wnt receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

KREMEN2 Products(4)

mRNA	Protein	Name
NM_001253725.2	NP_001240654.1	kremen protein 2 isoform e precursor
NM_001253726.2	NP_001240655.1	kremen protein 2 isoform f precursor
NM_024507.4	NP_078783.1	kremen protein 2 isoform b precursor
NM_172229.3	NP_757384.1	kremen protein 2 isoform d precursor

KREMEN2 Protein Structure

Kringle

WSC

CUB

0
100
200
300
400
462 a.a.

Protein Preferred Names

Protein Names

kremen protein 2

dickkopf receptor 2

Recombinant KREMEN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77976	Kremen-2 Protein, Human (HEK293, His)	Q8NCW0 (G26-A364)	≥95%

Related Diseases

Diseases

Alias

Sclerosteosis 2

SOST2

Sclerosteosis, Type 2

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities	Fetal Face Syndrome
Robinow Dwarfism	Mesomelic Dwarfism-Small Genitalia Syndrome
Robinow-Silverman-Smith Syndrome	Costovertebral Segmentation Defect With Mesomelia
Covesdem Syndrome	Robinow'S Syndrome
Robinow-Silverman Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07429	KREMEN2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	KREMEN2	MGD	MGI:1920266
Macaca mulatta	KREMEN2	VGNC	VGNC:74081
Felis catus	KREMEN2	VGNC	VGNC:63168
Rattus norvegicus	KREMEN2	RGD	RGD:1310795
Bos taurus	KREMEN2	VGNC	VGNC:58604
Canis familiaris	KREMEN2	VGNC	VGNC:42512
Macaca fascicularis	KREMEN2	NCBI
Others	KREMEN2	NCBI

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