RNF128 - ring finger protein 128 Gene

Homo sapiens

Also known as GRAIL

Gene ID: 79589 | Gene type: protein coding

About RNF128

Cytogenetic location: Xq22.3 Genomic coordinates (GRCh38): X:106,693,838-106,797,016 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 9 paralogues. Broad expression in small intestine (RPKM 27.8), liver (RPKM 27.8) and 15 other tissues.

Summary

The protein encoded by this gene is a type I transmembrane protein that localizes to the endocytic pathway. This protein contains a RING zinc-finger motif and has been shown to possess E3 ubiquitin ligase activity. Expression of this gene in retrovirally transduced T cell hybridoma significantly inhibits activation-induced IL2 and IL4 cytokine production. Induced expression of this gene was observed in anergic CD4(+) T cells, which suggested a role in the induction of anergic phenotype. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNF128 Products(2)

mRNA	Protein	Name
NM_024539.3	NP_078815.3	E3 ubiquitin-protein ligase RNF128 isoform 2 precursor
NM_194463.2	NP_919445.1	E3 ubiquitin-protein ligase RNF128 isoform 1 precursor

RNF128 Protein Structure

zf-RING_2

0
100
200
300
400
428 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF128

RING-type E3 ubiquitin transferase RNF128

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12046	RNF128 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNF128	VGNC	VGNC:64668
Macaca mulatta	RNF128	VGNC	VGNC:76792
Rattus norvegicus	RNF128	RGD	RGD:1566282
Mus musculus	RNF128	MGD	MGI:1914139
Bos taurus	RNF128	VGNC	VGNC:34019
Canis familiaris	RNF128	VGNC	VGNC:45628

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