SUGCT - succinyl-CoA:glutarate-CoA transferase Gene

Homo sapiens

Also known as GA3; ORF19; DERP13; C7orf10

Gene ID: 79783 | Gene type: protein coding

About SUGCT

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:40,135,005-41,038,816 (from NCBI)

This gene has 9 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in kidney (RPKM 3.4), liver (RPKM 1.2) and 12 other tissues.

Summary

This gene encodes a protein that is similar to members of the CaiB/baiF CoA-transferase protein family. Mutations in this gene are associated with glutaric aciduria type III. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

SUGCT Products(4)

mRNA	Protein	Name
NM_001193311.2	NP_001180240.2	succinate--hydroxymethylglutarate CoA-transferase isoform 1
NM_001193312.2	NP_001180241.2	succinate--hydroxymethylglutarate CoA-transferase isoform 2
NM_001193313.2	NP_001180242.2	succinate--hydroxymethylglutarate CoA-transferase isoform 3
NM_024728.3	NP_079004.2	succinate--hydroxymethylglutarate CoA-transferase isoform 4

SUGCT Protein Structure

CoA_transf_3

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

succinate--hydroxymethylglutarate CoA-transferase

Russel-Silver syndrome candidate

Related Diseases

Diseases

Alias

Glutaric Aciduria Iii

Glutaryl-Coa Oxidase Deficiency	Ga Iii
Glutaric Acidemia Type 3	GA3
Glutaric Aciduria Type 3	Glutaric Aciduria 3
Glutaric Acidemia Type Iii	Glutaric Aciduria Type Iii

Trichothiodystrophy

Ttd	Amish Brittle Hair Syndrome
Bids Syndrome	Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome
Ibids	Pibids
Trichothiodystrophy Syndromes

Robinow Syndrome, Autosomal Dominant 3

Autosomal Dominant Robinow Syndrome 3	DRS3
Robinow, Autosomal Dominant Syndrome, Type 3

Desmoid Disease, Hereditary

Fif	DESMD
Hereditary Desmoid Disease	Familial Infiltrative Fibromatosis
Fibromatosis, Familial Infiltrative	Fibromatosis, Aggressive

Amyotrophic Lateral Sclerosis 4, Juvenile

Amyotrophic Lateral Sclerosis Type 4	ALS4
Amyotrophic Lateral Sclerosis 4	Dhmn With Upper Motor Neuron Signs
Distal Hereditary Motor Neuropathy With Upper Motor Neuron Signs	Neuronopathy, Distal Hereditary Motor, With Pyramidal Features
Als 4	Distal Hereditary Motor Neuropathy With Pyramidal Features
Amyotrophic Lateral Sclerosis Juvenile 4	Neuronopathy Distal Hereditary Motor With Pyramidal Features
Sclerosis, Lateral, Amyotrophic, Type Type 4

Amyotrophic Lateral Sclerosis Type 6

Amyotrophic Lateral Sclerosis 6, Autosomal Recessive	Als6
Amyotrophic Lateral Sclerosis 6, With Or Without Frontotemporal Dementia	Autosomal Recessive Amyotrophic Lateral Sclerosis 6
Sclerosis, Lateral, Amyotrophic, Type Type 6	Amyotrophic Lateral Sclerosis 6

Nephronophthisis 3

NPHP3	Nph3
Adolescent Nephronophthisis	Nephronophthisis, Type 3

Glutaric Acidemia I

Glutaryl-Coa Dehydrogenase Deficiency	GA1
Glutaric Acidemia Type 1	Glutaric Aciduria 1
Glutaric Aciduria Type 1	Glutaric Acidemia Type I
Glutaric Aciduria, Type 1	Glutaric Aciduria I
Ga I	Glutaricaciduria, Type I
Glutaryl-Coenzyme A Dehydrogenase Deficiency	Glutaric Academia Type 1
Glutaric Aciduria Type I	Ga-1
Gcdh Deficiency	Ga 1
Glutaric Acidemia 1	Gcdhd
Glutaric Aciduria, Type I	Glutaricaciduria I
Ga-I	Glutaricaciduria, Type 1

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14008	SUGCT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SUGCT	MGD	MGI:1923221
Rattus norvegicus	SUGCT	RGD	RGD:1308114
Macaca mulatta	SUGCT	VGNC	VGNC:81767
Bos taurus	SUGCT	VGNC	VGNC:35462
Canis familiaris	SUGCT	VGNC	VGNC:52052
Felis catus	SUGCT	VGNC	VGNC:80727

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