2. Gene
  3. MMRN2 - multimerin 2 Gene

MMRN2 - multimerin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as EMILIN3; EMILIN-3; ENDOGLYX-1

Gene ID: 79812 | Gene type: protein coding

About MMRN2

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:86,935,540-86,957,615 (from NCBI)

This gene has 7 transcripts (splice variants), 183 orthologues and 4 paralogues. Broad expression in fat (RPKM 74.6), placenta (RPKM 22.4) and 20 other tissues.

Summary

This gene encodes a protein belonging to the member of elastin microfibril interface-located (EMILIN) protein family. This family member is an extracellular matrix glycoprotein that can interfere with tumor angiogenesis and growth. It serves as a transforming growth factor beta antagonist and can interfere with the VEGF-A/VEGFR2/KDR/Flk-1 pathway. A related pseudogene has been identified on chromosome 6. [provided by RefSeq, Aug 2012]

MMRN2 Products(1)

mRNA Protein Name
NM_024756.3 NP_079032.2 multimerin-2 precursor

MMRN2 Protein Structure

EMI

EMI: EMI domain (54 - 128)

C1q

C1q: C1q domain (827 - 946)

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  • 949 a.a.
Protein Preferred Names Protein Names

multimerin-2

EMILIN-like protein EndoGlyx-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08561 MMRN2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MMRN2 MGD MGI:2385618
Canis familiaris MMRN2 VGNC VGNC:43292
Felis catus MMRN2 VGNC VGNC:63540
Macaca mulatta MMRN2 VGNC VGNC:74797
Rattus norvegicus MMRN2 RGD RGD:1311461
Bos taurus MMRN2 VGNC VGNC:31533