2. Gene
  3. KDM8 - lysine demethylase 8 Gene

KDM8 - lysine demethylase 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as JMJD5

Gene ID: 79831 | Gene type: protein coding

About KDM8

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,203,526-27,221,768 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and 4 paralogues. Broad expression in liver (RPKM 13.5), small intestine (RPKM 5.4) and 18 other tissues.

Summary

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

KDM8 Products(2)

mRNA Protein Name
NM_001145348.2 NP_001138820.1 bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 1
NM_024773.3 NP_079049.2 bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 2

KDM8 Protein Structure

Cupin_8

Cupin_8: Cupin-like domain (194 - 415)

  • 0
  • 100
  • 200
  • 300
  • 416 a.a.
Protein Preferred Names Protein Names

bifunctional peptidase and arginyl-hydroxylase JMJD5

JmjC arginyl-hydroxylase

Related Diseases

Diseases Alias
Glycogen Storage Disease Xv

GSD15

Gsd Xv

Glycogenin Deficiency

Gyg1 Deficiency

Glycogen Storage Disease Type Xv

Glycogen Storage Disease With Severe Cardiomyopathy Due To Glycogenin Deficiency

Gsd Type 15

Gsd Type Xv

Gsd With Severe Cardiomyopathy Due To Glycogenin Deficiency

Glycogen Storage Disease Type 15

Glycogenosis Type 15

Glycogenosis Type Xv

Glycogenosis With Severe Cardiomyopathy Due To Glycogenin Deficiency

Glycogen Storage Disease 15

Storage Disease, Glycogen, Type Xv
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07225 KDM8 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KDM8 VGNC VGNC:80586
Mus musculus KDM8 MGD MGI:1924285
Bos taurus KDM8 VGNC VGNC:30534
Canis familiaris KDM8 VGNC VGNC:42330
Macaca mulatta KDM8 VGNC VGNC:81426
Rattus norvegicus KDM8 RGD RGD:1304823
Others KDM8 NCBI