RPAP2 - RNA polymerase II associated protein 2 Gene

Homo sapiens

Also known as Rtr1; C1orf82

Gene ID: 79871 | Gene type: protein coding

About RPAP2

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:92,299,059-92,402,056 (from NCBI)

This gene has 3 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in thyroid (RPKM 2.5), endometrium (RPKM 2.0) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Involved in dephosphorylation of RNA polymerase II C-terminal domain and snRNA transcription. Located in cytosol and nucleolus. Part of RNA polymerase II, holoenzyme. [provided by Alliance of Genome Resources, Apr 2022]

RPAP2 Products(1)

mRNA	Protein	Name
NM_024813.3	NP_079089.2	putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

RPAP2 Protein Structure

RPAP2_Rtr1

0
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300
400
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612 a.a.

Protein Preferred Names

Protein Names

putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

Related Diseases

Diseases

Alias

Cholestasis, Intrahepatic, Of Pregnancy, 1

ICP1	Intrahepatic Cholestasis Of Pregnancy 1
Cholestasis, Pregnancy-Related, 1	Pregnancy Related Cholestasis 1
Cholestasis Of Pregnancy, Intrahepatic 1	Obstetric Cholestasis
Pregnancy-Related Cholestasis	Recurrent Intrahepatic Cholestasis Of Pregnancy
Cholestasis, Intrahepatic, Of Pregnancy, Type 1	Cholestasis Of Pregnancy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12148	RPAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RPAP2	VGNC	VGNC:64729
Rattus norvegicus	RPAP2	RGD	RGD:1309034
Mus musculus	RPAP2	MGD	MGI:2141142
Bos taurus	RPAP2	VGNC	VGNC:34099
Macaca mulatta	RPAP2	VGNC	VGNC:76828

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