ASRGL1 - asparaginase and isoaspartyl peptidase 1 Gene

Homo sapiens

Also known as ALP; ALP1; CRASH

Gene ID: 80150 | Gene type: protein coding

About ASRGL1

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,337,448-62,401,431 (from NCBI)

This gene has 11 transcripts (splice variants), 211 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in testis (RPKM 38.7), kidney (RPKM 13.5) and 10 other tissues.

Summary

Enables asparaginase activity and beta-aspartyl-peptidase activity. Involved in asparagine catabolic process via L-aspartate. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ASRGL1 Products(2)

mRNA	Protein	Name
NM_001083926.2	NP_001077395.1	isoaspartyl peptidase/L-asparaginase
NM_025080.4	NP_079356.3	isoaspartyl peptidase/L-asparaginase

ASRGL1 Protein Structure

Asparaginase_2

0
100
200
308 a.a.

Protein Preferred Names

Protein Names

isoaspartyl peptidase/L-asparaginase

L-asparaginase

Related Diseases

Diseases

Alias

Immunodeficiency 48

Combined Immunodeficiency Due To Zap70 Deficiency	IMD48
Selective T-Cell Defect	Stcd
Zeta-Associated-Protein 70 Deficiency	Severe Combined Immunodeficiency, Atypical
Immunodeficiency, Type 48	Zap70 Deficiency

Aspartylglucosaminuria

Aspartylglycosaminuria	Glycosylasparaginase Deficiency
Aspartylglucosaminidase Deficiency	Aga Deficiency
AGU	Aspartylglucosamidase Deficiency
Glycoasparaginase	Aspartylglucosamidase Deficiency
Hyperammonemia, Type Iii

Corneal Dystrophy, Meesmann, 1

Meesmann Corneal Dystrophy	Mecd
Corneal Dystrophy, Meesmann Epithelial	Juvenile Hereditary Epithelial Dystrophy
Corneal Dystrophy, Juvenile Epithelial Of Meesmann	MECD1
Meesmann Corneal Dystrophy 1	Meesmann Corneal Epithelial Dystrophy
Meesmann Epithelial Corneal Dystrophy	Corneal Dystrophy, Juvenile Epithelial, Of Meesmann
Stocker-Holt Dystrophy	Meesman Dystrophy
Meesman'S Corneal Dystrophy	Juvenile Hereditary Epithelial Dystrophy Of Meesmann
Corneal Dystrophy, Meesmann 1	Juvenile Epithelial Corneal Dystrophy Of Meesmann
Mcd	Dystrophy, Corneal, Meesmann

Normal Pressure Hydrocephalus

Low Pressure Hydrocephalus	Hydrocephalus Normal Pressure
Hydrocephalus, Normal Pressure	Normal Pressure Hydrocephalus Nos
Nph - [Normal Pressure Hydrocephalus]	Normal Pressure Hydrocephaly

Retinal Degeneration

Degeneration Of Retina

Cone-Rod Dystrophy 2

Cone-Rod Dystrophy	CORD2
Cone-Rod Retinal Dystrophy	Rcrd2
Cone-Rod Retinal Dystrophy 2	Crd2
Cord	Crd
Retinal Cone-Rod Dystrophy	Cone-Rod Retinal Dystrophy-2
Retinal Cone-Rod Dystrophy 2	Tapetoretinal Degeneration
Cone-Rod Degeneration	Cone Rod Dystrophy
Dystrophy, Cone-Rod	Dystrophy, Cone-Rod, Type 2
Retinitis Pigmentosa	Retinitis Pigmentosa 2
Progressive Cone-Rod Dystrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01108	ASRGL1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ASRGL1	VGNC	VGNC:70081
Bos taurus	ASRGL1	VGNC	VGNC:26223
Mus musculus	ASRGL1	MGD	MGI:1913764
Canis familiaris	ASRGL1	VGNC	VGNC:38192
Felis catus	ASRGL1	VGNC	VGNC:59980
Rattus norvegicus	ASRGL1	RGD	RGD:708526

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