SCUBE1 - signal peptide, CUB domain and EGF like domain containing 1 Gene

Homo sapiens

Gene ID: 80274 | Gene type: protein coding

About SCUBE1

Cytogenetic location: 22q13.2 Genomic coordinates (GRCh38): 22:43,197,280-43,343,372 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues and 2 paralogues. Broad expression in ovary (RPKM 8.0), testis (RPKM 5.9) and 17 other tissues.

Summary

This gene encodes a cell surface glycoprotein that is a member of the SCUBE (signal peptide, CUB domain, EGF (epidermal growth factor)-like protein) family. Family members have an amino-terminal signal peptide, nine copies of EGF-like repeats and a CUB domain at the carboxyl terminus. This protein is expressed in platelets and endothelial cells and may play an important role in vascular biology. [provided by RefSeq, Oct 2011]

SCUBE1 Products(1)

mRNA	Protein	Name
NM_173050.5	NP_766638.2	signal peptide, CUB and EGF-like domain-containing protein 1 precursor

SCUBE1 Protein Structure

EGF_3

cEGF

FXa_inhibition

EGF_CA

Ephrin_rec_like

CUB

0
200
400
600
800
988 a.a.

Protein Preferred Names

Protein Names

signal peptide, CUB and EGF-like domain-containing protein 1

signal peptide, CUB domain, EGF-like 1

Related Diseases

Diseases

Alias

Mixed Receptive-Expressive Language Disorder

Crimean-Congo Hemorrhagic Fever

Crimean Hemorrhagic Fever	Cchf
Congo Hemorrhagic Fever	Hemorrhagic Fever, Crimean
Chf Congo Virus	Congo-Crimean Hemorrhagic Fever
Congo Fever	Hemorrhagic Fever Crimean-Congo
Cchf - [Crimean-Congo Haemorrhagic Fever]	Kara Mikh Typhoid Fever
Xīnjiāng Haemorrhagic Fever

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12571	SCUBE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCUBE1	RGD	RGD:1309015
Bos taurus	SCUBE1	VGNC	VGNC:34371
Canis familiaris	SCUBE1	VGNC	VGNC:45935
Macaca mulatta	SCUBE1	VGNC	VGNC:77008
Mus musculus	SCUBE1	MGD	MGI:1890616

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