2. Gene
  3. CAPZB - capping actin protein of muscle Z-line subunit beta Gene

CAPZB - capping actin protein of muscle Z-line subunit beta Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CAPB; CAPZ; CAPPB

Gene ID: 832 | Gene type: protein coding

About CAPZB

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,338,775-19,485,539 (from NCBI)

This gene has 15 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in appendix (RPKM 43.9), lymph node (RPKM 41.5) and 25 other tissues.

Summary

This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013]

CAPZB Products(5)

mRNA Protein Name
NM_001206540.3 NP_001193469.1 F-actin-capping protein subunit beta isoform 2
NM_001206541.3 NP_001193470.1 F-actin-capping protein subunit beta isoform 3
NM_001282162.2 NP_001269091.1 F-actin-capping protein subunit beta isoform 4
NM_001313932.2 NP_001300861.1 F-actin-capping protein subunit beta isoform 5
NM_004930.5 NP_004921.1 F-actin-capping protein subunit beta isoform 1

CAPZB Protein Structure

F_actin_cap_B

F_actin_cap_B: F-actin capping protein, beta subunit (5 - 240)

  • 0
  • 100
  • 200
  • 277 a.a.
Protein Preferred Names Protein Names

F-actin-capping protein subunit beta

capZ beta

Related Diseases

Diseases Alias
Progressive Pseudorheumatoid Dysplasia

Progressive Pseudorheumatoid Arthropathy Of Childhood

Arthropathy, Progressive Pseudorheumatoid, Of Childhood

Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy

Ppd

Ppac

Sedt-Pa

Spondyloepiphyseal Dysplasia Tarda-Progressive Arthropathy Syndrome

PPRD

Progressive Pseudorheumatoid Chondrodysplasia

Spondyloepiphyseal Dysplasia Tarda - Progressive Arthropathy

Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy

Dysplasia, Pseudorheumatoid, Progressive
Skin Carcinoma In Situ

Carcinoma In Situ Of Skin

Cutaneous Carcinoma In Situ
Hemoglobin E Disease

Hemoglobin E

Hb-E Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01904 CAPZB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CAPZB VGNC VGNC:52114
Macaca mulatta CAPZB VGNC VGNC:70539
Rattus norvegicus CAPZB RGD RGD:1359099
Mus musculus CAPZB MGD MGI:104652
Bos taurus CAPZB VGNC VGNC:26759
Felis catus CAPZB VGNC VGNC:60362