EPPK1 - epiplakin 1 Gene

Homo sapiens

Also known as EPIPL; EPIPL1

Gene ID: 83481 | Gene type: protein coding

About EPPK1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:143,857,324-143,879,194 (from NCBI)

This gene has 2 transcripts (splice variants), 91 orthologues and 36 paralogues. Biased expression in skin (RPKM 9.0), colon (RPKM 7.5) and 10 other tissues.

Summary

The protein encoded by this gene belongs to the plakin family of proteins, which play a role in the organization of cytoskeletal architecture. This family member is composed of several highly homologous plakin repeats. It may function to maintain the integrity of keratin intermediate filament networks in epithelial cells. Studies of the orthologous mouse protein suggest that it accelerates keratinocyte migration during wound healing. [provided by RefSeq, Oct 2013]

EPPK1 Products(1)

mRNA	Protein	Name
NM_031308.4	NP_112598.3	epiplakin

EPPK1 Protein Structure

Plectin

0
400
800
1200
1600
2000
2420 a.a.

Protein Preferred Names

Protein Names

epiplakin

450 kDa epidermal antigen

Related Diseases

Diseases

Alias

Melanotic Medulloblastoma

Medulloblastoma, Melanotic

Paraneoplastic Pemphigus

Sarcomatosis

Maxillary Cancer

Maxillary Neoplasm	Maxillary Neoplasms
Upper Jaw Bone Cancer

Subcorneal Pustular Dermatosis

Subcorneal Pustular Dermatitis	Sneddon-Wilkinson Disease Or Syndrome
Pustulosis Subcornealis	Sneddon-Wilkinson Disease
Skin Diseases, Vesiculobullous	Vesiculobullous Skin Disease

Jaw Cancer

Jaw Neoplasms	Jaw Neoplasm
Neoplasm Of Jaw	Cancer Of Jaw

Bullous Skin Disease

Skin Diseases Bullous

Skin Diseases, Bullous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04450	EPPK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	EPPK1	RGD	RGD:1587023
Mus musculus	EPPK1	MGD	MGI:2386306
Bos taurus	EPPK1	VGNC	VGNC:106726

Name
Email *

	Sorry, but the email address you supplied was invalid.