Ppargc1a - PPARG coactivator 1 alpha Gene

Also known as PGCvf; LRPGC1; PGC-1v; PGCvf1; PGCvf-1; Ppargc1

About Ppargc1a

Summary

Enables several functions, including alpha-tubulin binding activity; Estrogen Receptor binding activity; and peroxisome proliferator activated receptor binding activity. Involved in several processes, including cellular response to hexose stimulus; cellular response to organic cyclic compound; and regulation of smooth muscle cell proliferation. Located in several cellular components, including apical dendrite; cytosolic ribosome; and euchromatin. Used to study several diseases, including fatty liver disease (multiple); glucose metabolism disease (multiple); heart disease (multiple); neurodegenerative disease (multiple); and sciatic neuropathy. Biomarker of several diseases, including Huntington's disease; glucose metabolism disease (multiple); placental insufficiency; primary biliary cholangitis; and renal fibrosis. Human ortholog(s) of this gene implicated in several diseases, including macular degeneration; malignant fibrous histiocytoma; neurodegenerative disease (multiple); non-alcoholic fatty liver disease; and type 2 diabetes mellitus. Orthologous to human PPARGC1A (PPARG coactivator 1 alpha). [provided by Alliance of Genome Resources, Apr 2022]