2. Gene
  3. DYNLRB1 - dynein light chain roadblock-type 1 Gene

DYNLRB1 - dynein light chain roadblock-type 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BLP; BITH; DNCL2A; DNLC2A; ROBLD1

Gene ID: 83658 | Gene type: protein coding

About DYNLRB1

Cytogenetic location: 20q11.22 Genomic coordinates (GRCh38): 20:34,515,602-34,540,958 (from NCBI)

This gene has 5 transcripts (splice variants), 162 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 34.0), kidney (RPKM 31.8) and 25 other tissues.

Summary

This gene is a member of the roadblock dynein LIGHT chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013]

DYNLRB1 Products(5)

mRNA Protein Name
NM_001319157.2 NP_001306086.1 dynein light chain roadblock-type 1 isoform d
NM_001382365.1 NP_001369294.1 dynein light chain roadblock-type 1 isoform a
NM_001382366.1 NP_001369295.1 dynein light chain roadblock-type 1 isoform e
NM_001382367.1 NP_001369296.1 dynein light chain roadblock-type 1 isoform f
NM_014183.4 NP_054902.1 dynein light chain roadblock-type 1 isoform a

DYNLRB1 Protein Structure

Robl_LC7

Robl_LC7: Roadblock/LC7 domain (4 - 93)

  • 0
  • 96 a.a.
Protein Preferred Names Protein Names

dynein light chain roadblock-type 1

ROBL/LC7-like 1

Related Diseases

Diseases Alias
Tuberculous Empyema

Empyema, Tuberculous

Empyema Tuberculous
Vestibular Nystagmus

Nystagmus Associated With Disorder Of The Vestibular System
Asphyxiating Thoracic Dystrophy

Jeune Thoracic Dystrophy

Jeune Syndrome

Asphyxiating Thoracic Dysplasia

Short-Rib Thoracic Dysplasia With Or Without Polydactyly

Thoracic Pelvic Phalangeal Dystrophy

Asphyxiating Thoracic Chondrodystrophy

Atd

Chondroectodermal Dysplasia-Like Syndrome

Infantile Thoracic Dystrophy

Jeune Thoracic Dysplasia

Thoracic Asphyxiant Dystrophy

Thoracic-Pelvic-Phalangeal Dystrophy

Short-Rib Thoracic Dysplasia Without Polydactyly

Asphyxiating Thoracic Dystrophy Of The Newborn

Asphyxiating Thorax Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04090 DYNLRB1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DYNLRB1 VGNC VGNC:40152
Bos taurus DYNLRB1 VGNC VGNC:28276
Felis catus DYNLRB1 VGNC VGNC:61682
Macaca mulatta DYNLRB1 VGNC VGNC:71839
Rattus norvegicus DYNLRB1 RGD RGD:619910
Mus musculus DYNLRB1 MGD MGI:1914318