2. Gene
  3. ATG10 - autophagy related 10 Gene

ATG10 - autophagy related 10 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as APG10; APG10L; pp12616

Gene ID: 83734 | Gene type: protein coding

About ATG10

Cytogenetic location: 5q14.1-q14.2 Genomic coordinates (GRCh38): 5:81,972,023-82,256,133 (from NCBI)

This gene has 9 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in testis (RPKM 1.1), thyroid (RPKM 0.8) and 25 other tissues.

Summary

Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like Enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

ATG10 Products(2)

mRNA Protein Name
NM_001131028.2 NP_001124500.1 ubiquitin-like-conjugating enzyme ATG10
NM_031482.5 NP_113670.1 ubiquitin-like-conjugating enzyme ATG10

ATG10 Protein Structure

Autophagy_act_C

Autophagy_act_C: Autophagocytosis associated protein, active-site domain (99 - 167)

  • 0
  • 100
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  • 220 a.a.
Protein Preferred Names Protein Names

ubiquitin-like-conjugating enzyme ATG10

APG10 autophagy 10-like

Recombinant ATG10 Proteins

Cat. No. Product Name Accession Purity
HY-P7616 ATG10 Protein, Human (His-T7) Q9H0Y0 (M1-T190) ≥95%

Related Diseases

Diseases Alias
Neurodegeneration With Brain Iron Accumulation

Nbia

Neurodegeneration With Brain Iron Accumulation Disorders

Neurodegeneration, With Brain Iron Accumulation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01138 ATG10 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ATG10 VGNC VGNC:26248
Mus musculus ATG10 MGD MGI:1914045
Felis catus ATG10 VGNC VGNC:102164
Macaca mulatta ATG10 VGNC VGNC:70102
Canis familiaris ATG10 VGNC VGNC:38214
Rattus norvegicus ATG10 RGD RGD:1587624
Others ATG10 NCBI