2. Gene
  3. Src - SRC proto-oncogene, non-receptor tyrosine kinase Gene

Src - SRC proto-oncogene, non-receptor tyrosine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 83805 | Gene type: protein coding

About Src

Primary_assembly 3: 146,091,841-146,139,476 forward strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 261 orthologues, 32 paralogues and is associated with 42 phenotypes. Biased expression in Brain (RPKM 86.6), Lung (RPKM 78.5) and 9 other tissues.

Summary

Enables several functions, including Estrogen Receptor binding activity; Insulin Receptor binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to lipid; positive regulation of phosphorylation; and regulation of signal transduction. Located in caveola; neuron projection; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic specialization, intracellular component. Used to study Parkinsonism; brain ischemia; hypertension; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in colorectal Cancer (multiple); ductal carcinoma in situ; prostate cancer; thrombocytopenia; and type 2 diabetes mellitus. Orthologous to human Src (Src proto-oncogene, non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Src Products(1)

mRNA Protein Name
NM_031977.1 NP_114183.1 proto-oncogene tyrosine-protein kinase Src

Src Protein Structure

SH3_Src

SH3_Src: cd12008 (87 - 148)

SH2_Src_Src

SH2_Src_Src: cd10365 (152 - 252)

PTKc_Src

PTKc_Src: cd05071 (265 - 541)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 542 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase Src

Rous sarcoma oncogene

c-Src

p60-Src

pp60c-src

proto-oncogene c-Src

tyrosine protein kinase c-src

tyrosine protein kinase pp60-c-src

v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog

Related Agents

Approval
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10181 Dasatinib Inhibitor 99.88% Yes
HY-12047 Ponatinib Inhibitor 99.43% Yes
HY-10158 Bosutinib Inhibitor 99.96% Yes
HY-10209 Masitinib Inhibitor 99.98% Yes
HY-10181A Dasatinib hydrochloride Inhibitor 98.86% Yes
HY-108766 Ponatinib hydrochloride Inhibitor 99.55% Yes
HY-10209A Masitinib mesylate Inhibitor 99.83% Yes
Clinical Phase
Bioactive Molecules (18)
Cat. No. Product Name Effect
Purity Phase
HY-10234 Saracatinib Inhibitor 99.92% Phase 3
HY-10340 Tirbanibulin Inhibitor 99.56% Phase 3
HY-10340A Tirbanibulin dihydrochloride Inhibitor 99.59% Phase 3
HY-10340B Tirbanibulin Mesylate Inhibitor 99.97% Phase 3
HY-13024 Rebastinib Inhibitor 99.91% Phase 2
HY-50868 Bafetinib Inhibitor 99.77% Phase 2
HY-15323 PRT062607 Hydrochloride Inhibitor 98.68% Phase 2
HY-32718 Pelitinib Inhibitor 98.80% Phase 2
HY-59047 Tolimidone Activator 99.89% Phase 2
HY-111787 Elzovantinib Inhibitor 99.97% Phase 2
HY-10987A ENMD-2076 Inhibitor 99.12% Phase 2
HY-10987 ENMD-2076 Tartrate Inhibitor 99.42% Phase 2
HY-10186 TG 100801 Inhibitor 98.60% Phase 2
HY-10187 TG 100801 Hydrochloride Inhibitor / Phase 2
HY-15749 XL228 Inhibitor 99.29% Phase 1
HY-10032 PF 477736 Inhibitor 99.21% Phase 1
HY-112809 GSK2646264 Inhibitor 98.39% Phase 1
HY-112314 AZD0424 Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (105)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13805 PP2 Inhibitor 99.35% Unkown
HY-12299 WH-4-023 Inhibitor 99.75% Unkown
HY-15764A A 419259 trihydrochloride Inhibitor 99.21% Unkown
HY-12072 Lck Inhibitor Inhibitor 99.45% Unkown
HY-13804 PP1 Inhibitor 99.00% Unkown
HY-B0789 SU6656 Inhibitor 98.05% Unkown
HY-101053 Src Inhibitor 1 Inhibitor 99.96% Unkown
HY-112096 eCF506 Inhibitor 99.30% Unkown
HY-13942 1-NM-PP1 Inhibitor 99.28% Unkown
HY-136848 SM1-71 Inhibitor 96.00% Unkown
HY-13941 1-Naphthyl PP1 Inhibitor 99.08% Unkown
HY-N0752 Scutellarein Inhibitor 99.25% Unkown
HY-135299 CH6953755 Inhibitor 98.03% Unkown
HY-112852 TL02-59 Inhibitor 99.84% Unkown
HY-130254 Src Inhibitor 3 Inhibitor 98.61% Unkown
HY-11011 A-770041 Inhibitor 99.95% Unkown
HY-108318 RK-24466 Inhibitor 98.53% Unkown
HY-10395 PD173955 Inhibitor 99.12% Unkown
HY-W062835 CGP77675 Inhibitor 99.00% Unkown
HY-10372 PP121 Inhibitor 98.67% Unkown
HY-13561 AZM475271 Inhibitor 99.85% Unkown
HY-112182 UM-164 Inhibitor 99.15% Unkown
HY-P3279 EPQpYEEIPIYL Activator 98.94% Unkown
HY-15764 A 419259 Inhibitor 98.23% Unkown
HY-18303 AMG-47a Inhibitor 99.34% Unkown
HY-101963 AD80 Inhibitor 99.88% Unkown
HY-136605 DGY-06-116 Inhibitor 99.54% Unkown
HY-139147 iHCK-37 Inhibitor 99.69% Unkown
HY-78263 MNS Inhibitor 99.55% Unkown
HY-155657 BT424 Inhibitor 98.81% Unkown
HY-10644 Lck inhibitor 2 Inhibitor 99.81% Unkown
HY-10185 TG 100572 Hydrochloride Inhibitor 98.96% Unkown
HY-13941B 1-Naphthyl PP1 hydrochloride Inhibitor 99.94% Unkown
HY-108485 Damnacanthal Inhibitor ≥98.0% Unkown
HY-120213 YH-306 Inhibitor 98.01% Unkown
HY-18622 PP58 Inhibitor 99.75% Unkown
HY-P1377A Caffeic acid-pYEEIE TFA 98.50% Unkown
HY-107024 Osteogenic Growth Peptide (10-14) Inhibitor 99.77% Unkown
HY-108488 KB SRC 4 Inhibitor 99.66% Unkown
HY-127002 Squarunkin A Inhibitor 99.34% Unkown
HY-103274 PD180970 Inhibitor 99.27% Unkown
HY-153556 GW297361 Inhibitor 98.13% Unkown
HY-112345 PD-089828 Inhibitor 98.07% Unkown
HY-163144 DAS-5-oCRBN Degrader 98.08% Unkown
HY-125028 Hck-IN-1 Inhibitor 98.53% Unkown
HY-N4201 β-Hydroxyisovalerylshikonin Inhibitor 99.83% Unkown
HY-118144 PD166326 Inhibitor 99.99% Unkown
HY-120595 JNJ-49095397 Inhibitor 99.85% Unkown
HY-132150A HPK1-IN-2 dihydrochloride Inhibitor 98.69% Unkown
HY-W013857 Lavendustin C Inhibitor 98.32% Unkown
HY-N6596 7-Hydroxy-4-chromone Inhibitor 99.94% Unkown
HY-N4127 3'-Demethylnobiletin 99.98% Unkown
HY-122113 PD173952 Inhibitor 98.82% Unkown
HY-123506 Fenlean Inhibitor 99.56% Unkown
HY-18237 KX1-004 Inhibitor 99.75% Unkown
HY-18507 AD57 Inhibitor 98.08% Unkown
HY-10158S Bosutinib-d8 Inhibitor ≥99.0% Unkown
HY-15764G A 419259 (GMP) Inhibitor / Unkown
HY-10184 TG 100572 Inhibitor / Unkown
HY-10234A Saracatinib difumarate Inhibitor 99.24% Yes
HY-157998 mG2N001 / Unkown
HY-112852A TL02-59 dihydrochloride Inhibitor / Unkown
HY-15324 PRT062607 acetate Inhibitor 99.83% Unkown
HY-W745090 Isomaltulose monohydrate Inhibitor / Unkown
HY-P1111 Lyn peptide inhibitor Inhibitor / Unkown
HY-102073 TG53 Inhibitor / Unkown
HY-157497 DA5-HTL Inhibitor / Unkown
HY-10363 AP 24149 Inhibitor / Unkown
HY-112335 Lck Inhibitor III Inhibitor / Unkown
HY-123298 Chrysotoxine Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-P1377 Caffeic acid-pYEEIE / Unkown
HY-W062835A CGP77675 hydrate Inhibitor / Unkown
HY-162291 Lck-IN-3 Inhibitor / Unkown
HY-146014 Multi-kinase-IN-1 Inhibitor / Unkown
HY-157290 HL403 Inhibitor / Unkown
HY-P1200A Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA Inhibitor / Unkown
HY-13342AS Apatinib-d8 free base 92.56% Unkown
HY-115723 Antiallergic agent-1 Inhibitor / Unkown
HY-147314 HIV-IN-6 98.35% Unkown
HY-W744699 Larixol Inhibitor / Unkown
HY-110367A LCB 03-0110 Inhibitor / Unkown
HY-15268 PP487 Inhibitor / Unkown
HY-P2547 Tyrosine Kinase Peptide 1 / Unkown
HY-128397 CpCDPK1/TgCDPK1-IN-1 Inhibitor / Unkown
HY-111187 KX2-361 Inhibitor 99.55% Unkown
HY-112291 SB 220025 Inhibitor / Unkown
HY-138202 Lck-IN-1 Inhibitor / Unkown
HY-139890 DC-Srci-6649 Inhibitor / Unkown
HY-150026 Multi-kinase-IN-2 Inhibitor / Unkown
HY-110367 LCB 03-0110 dihydrochloride Inhibitor / Unkown
HY-163278 Lck-IN-2 Inhibitor / Unkown
HY-P1200 Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH Inhibitor / Unkown
HY-18507A AD57 hydrochloride Inhibitor / Unkown
HY-12847 CCT241161 Inhibitor / Unkown
HY-162413 (R)-LW-Srci-8 Inhibitor / Unkown
HY-127002A Squarunkin A hydrochloride Inhibitor / Unkown
HY-15814 HG-7-85-01 Inhibitor 99.94% Unkown
HY-P1111A Lyn peptide inhibitor TFA Inhibitor / Unkown
HY-108016 Peruvoside Inhibitor / Unkown
HY-15805 KIN-8194 Inhibitor / Unkown
HY-P3773 p60c-src substrate II / Unkown
HY-112096S eCF506-d5 Inhibitor / Unkown
HY-N7160 2-Hydroxy-3-methylanthraquinone Inhibitor / Unkown
HY-W700620 Hydroxymethyl dasatinib Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Src NCBI NCBI:6714
Mus musculus Src NCBI NCBI:20779