2. Gene
  3. PIP5K1A - phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Gene

PIP5K1A - phosphatidylinositol-4-phosphate 5-kinase type 1 alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8394 | Gene type: protein coding

About PIP5K1A

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:151,195,419-151,249,531 (from NCBI)

This gene has 17 transcripts (splice variants), 239 orthologues and 6 paralogues. Ubiquitous expression in testis (RPKM 22.2), placenta (RPKM 13.0) and 25 other tissues.

Summary

Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and kinase binding activity. Involved in several processes, including activation of GTPase activity; focal adhesion assembly; and ruffle assembly. Located in several cellular components, including lamellipodium; nuclear speck; and ruffle membrane. Colocalizes with mRNA cleavage and polyadenylation specificity factor complex. [provided by Alliance of Genome Resources, Apr 2022]

PIP5K1A Products(5)

mRNA Protein Name
NM_001135636.2 NP_001129108.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3
NM_001135637.2 NP_001129109.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 4
NM_001135638.2 NP_001129110.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1
NM_001330689.2 NP_001317618.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 5
NM_003557.3 NP_003548.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2

PIP5K1A Protein Structure

PIP5K

PIP5K: Phosphatidylinositol-4-phosphate 5-Kinase (164 - 448)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 562 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10566 PIP5K1A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PIP5K1A VGNC VGNC:55656
Mus musculus PIP5K1A MGD MGI:107929
Macaca mulatta PIP5K1A VGNC VGNC:100037
Felis catus PIP5K1A VGNC VGNC:80303
Rattus norvegicus PIP5K1A RGD RGD:1306127