KAT8 - lysine acetyltransferase 8 Gene

Homo sapiens

Also known as MOF; hMOF; MYST1; LIGOWS; ZC2HC8

Gene ID: 84148 | Gene type: protein coding

About KAT8

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,117,664-31,131,393 (from NCBI)

This gene has 8 transcripts (splice variants), 189 orthologues, 9 paralogues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 17.1), testis (RPKM 11.9) and 25 other tissues.

Summary

This gene encodes a member of the MYST histone acetylase protein family. The encoded protein has a characteristic MYST domain containing an acetyl-CoA-binding site, a chromodomain typical of proteins which bind histones, and a C2HC-type zinc finger. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

KAT8 Products(2)

mRNA	Protein	Name
NM_032188.3	NP_115564.2	histone acetyltransferase KAT8 isoform 1
NM_182958.4	NP_892003.2	histone acetyltransferase KAT8 isoform 2

KAT8 Protein Structure

Tudor-knot

MOZ_SAS

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

histone acetyltransferase KAT8

K(lysine) acetyltransferase 8

Related Diseases

Diseases

Alias

Li-Ghorbani-Weisz-Hubshman Syndrome

LIGOWS

Li-Ghorgani-Weisz-Hubshman Syndrome

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Koolen-De Vries Syndrome

KDVS	17q21.31 Microdeletion Syndrome
Microdeletion 17q21.31 Syndrome	Chromosome 17q21.31 Deletion Syndrome
Koolen De Vries Syndrome	Kansl1-Related Intellectual Disability Syndrome
Chromosome 17q21.31 Microdeletion Syndrome	Monosomy 17q21.31
17q21.31 Deletion Syndrome	Koolen Syndrome
Del(17)(Q21.31)

Capgras Syndrome

Capgras Delusion Theory

Haverhill Fever

Streptobacillosis	Streptobacillary Rat-Bite Fever
Streptobacillary Fever	Rat-Bite Fever Due To Streptobacillus Moniliformis
Erythema Arthriticum Epidemicum	Epidemic Arthritic Erythema

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W015239	KAT8-IN-1		99.40%	Unkown
HY-149302	MC4033		99.77%	Unkown
HY-153604	MC4171	Inhibitor	98.68%	Unkown
HY-RS07084	KAT8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KAT8	VGNC	VGNC:63027
Rattus norvegicus	KAT8	RGD	RGD:1311512
Mus musculus	KAT8	MGD	MGI:1915023
Macaca mulatta	KAT8	VGNC	VGNC:99520
Bos taurus	KAT8	VGNC	VGNC:30404
Canis familiaris	KAT8	VGNC	VGNC:42215
Others	KAT8	NCBI

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