ANTXR1 - ANTXR cell adhesion molecule 1 Gene

Homo sapiens

Also known as ATR; GAPO; TEM8

Gene ID: 84168 | Gene type: protein coding

About ANTXR1

Cytogenetic location: 2p13.3 Genomic coordinates (GRCh38): 2:69,013,144-69,249,327 (from NCBI)

This gene has 11 transcripts (splice variants), 268 orthologues, 2 paralogues and is associated with 5 phenotypes. Broad expression in gall bladder (RPKM 37.4), ovary (RPKM 30.6) and 21 other tissues.

Summary

This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal Cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described. [provided by RefSeq, Oct 2008]

ANTXR1 Products(4)

mRNA	Protein	Name
NM_001410840.1	NP_001397769.1	anthrax toxin receptor 1 isoform 4 precursor
NM_018153.3	NP_060623.2	anthrax toxin receptor 1 isoform 3 precursor
NM_032208.3	NP_115584.1	anthrax toxin receptor 1 isoform 1 precursor
NM_053034.2	NP_444262.1	anthrax toxin receptor 1 isoform 2 precursor

ANTXR1 Protein Structure

VWA

Anth_Ig

Ant_C

0
100
200
300
400
500
564 a.a.

Protein Preferred Names

Protein Names

anthrax toxin receptor 1

2310008J16Rik

Recombinant ANTXR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7521	TEM8/ANTXR1 Protein, Human	Q9H6X2-4 (E33-K321)	≥95%
HY-P77226	TEM8/ANTXR1 Protein, Human (HEK293, Fc)	Q9H6X2 (M1-S321)	≥95%

Related Diseases

Diseases

Alias

Gapo Syndrome

GAPOS	Growth Retardation, Alopecia, Pseudoanodontia, And Optic Atrophy
Growth Delay-Alopecia-Pseudoanodontia-Optic Atrophy Syndrome	Growth Retardation, Alopecia, Pseudoanodontia And Optic Atrophy

Hemangioma, Capillary Infantile

HCI	Capillary Infantile Hemangioma
Hemangioma, Hereditary Capillary	Hemangioma, Capillary Infantile, Susceptibility To
Hemangioma, Capillary Infantile, Somatic	Hemangioma Hereditary Capillary

Anthrax Disease

Anthrax	Ragpicker'S Disease
Black Baine	Malignant Edema
Malignant Pustule	Siberian Plague
Wool Sorter'S Disease	Gas Gangrene
Cutaneous Anthrax	Anthrax Infection
Splenic Fever

Hemangioma

Hemangiomas

Hyaline Fibromatosis Syndrome

Juvenile Hyaline Fibromatosis	Inherited Systemic Hyalinosis
Puretic Syndrome	Infantile Systemic Hyalinosis
HFS	Hyalinosis, Systemic
Systemic Hyalinosis	Molluscum Fibrosum
Murray Syndrome	Murray-Puretic-Drescher Syndrome
Ish	Jhf
Fibromatosis, Juvenile Hyaline	Hyalinosis, Systemic Infantile
Fibromatosis, Hyaline Syndrome	Neurofibromatosis 1

Cutaneous Anthrax

Anthrax, Skin Type

Skin Anthrax

Inhalation Anthrax

Pulmonary Anthrax	Respiratory Anthrax
Inhalational Anthrax	Wool-Sorters' Disease
Woolsorters' Disease	Inhalation Anthrax Disease
Respiratory Anthrax Disease

Gastrointestinal Anthrax

Oropharyngeal Anthrax

Gingival Hypertrophy

Hypertrophy Of Gingivae

Capillary Hemangioma

Infantile Hemangioma	Strawberry Nevus Of Skin
Cellular Hemangioma Of Infancy	Congenital Vascular Hamartoma
Congenital Vascular Naevus	Juvenile Hemangioma
Strawberry Haemangioma	Strawberry Nevus
Hemangioma Capillary	Hemangioma, Capillary
Hemangioma, Cavernous

Bardet-Biedl Syndrome 2

BBS2	Bardet-Biedl Syndrome
Bardet-Biedl Syndrome, Type 2	Bbs

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Capillary Disease

Disease Of Capillaries

Robinow Syndrome, Autosomal Recessive 1

Robinow Syndrome, Autosomal Recessive	Autosomal Recessive Robinow Syndrome
Covesdem Syndrome	RRS1
Costovertebral Segmentation Defect-Mesomelia Syndrome	Rrs
Costovertebral Segmentation Defect With Mesomelia, Formerly	Covesdem Syndrome, Formerly
Costovertebral Segmentation Defect With Mesomelia	Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly	Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals
Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly	Robinow, Autosomal Recessive Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00755	ANTXR1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANTXR1	VGNC	VGNC:37935
Rattus norvegicus	ANTXR1	RGD	RGD:1307144
Macaca mulatta	ANTXR1	VGNC	VGNC:69873
Felis catus	ANTXR1	VGNC	VGNC:59837
Bos taurus	ANTXR1	VGNC	VGNC:25961
Mus musculus	ANTXR1	MGD	MGI:1916788
Others	ANTXR1	NCBI

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