2. Gene
  3. SETD3 - SET domain containing 3, actin histidine methyltransferase Gene

SETD3 - SET domain containing 3, actin histidine methyltransferase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as hSETD3; C14orf154

Gene ID: 84193 | Gene type: protein coding

About SETD3

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:99,397,748-99,486,458 (from NCBI)

This gene has 9 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 33.6), kidney (RPKM 26.5) and 25 other tissues.

Summary

Enables protein-L-histidine N-tele-methyltransferase activity. Involved in actin modification and peptidyl-histidine methylation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

SETD3 Products(2)

mRNA Protein Name
NM_032233.3 NP_115609.2 actin-histidine N-methyltransferase isoform a
NM_199123.2 NP_954574.1 actin-histidine N-methyltransferase isoform b

SETD3 Protein Structure

SET

SET: SET domain (105 - 314)

Rubis-subs-bind

Rubis-subs-bind: Rubisco LSMT substrate-binding (343 - 475)

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  • 594 a.a.
Protein Preferred Names Protein Names

actin-histidine N-methyltransferase

SET domain-containing protein 3

Related Diseases

Diseases Alias
Acute Flaccid Myelitis
Sotos Syndrome 3

Sotos3

Sotos Syndrome, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12743 SETD3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SETD3 RGD RGD:1309550
Bos taurus SETD3 VGNC VGNC:34494
Canis familiaris SETD3 VGNC VGNC:46055
Mus musculus SETD3 MGD MGI:1289184
Felis catus SETD3 VGNC VGNC:65042
Macaca mulatta SETD3 VGNC VGNC:77285