MAF1 - MAF1 homolog, negative regulator of RNA polymerase III Gene

Homo sapiens

Gene ID: 84232 | Gene type: protein coding

About MAF1

Cytogenetic location: 8q24.3 Genomic coordinates (GRCh38): 8:144,104,461-144,107,611 (from NCBI)

This gene has 6 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in fat (RPKM 39.1), ovary (RPKM 34.7) and 25 other tissues.

Summary

This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]

MAF1 Products(1)

mRNA	Protein	Name
NM_032272.5	NP_115648.2	repressor of RNA polymerase III transcription MAF1 homolog

MAF1 Protein Structure

Maf1

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

repressor of RNA polymerase III transcription MAF1 homolog

MAF1 negative regulator of RNA polymerase III

Related Diseases

Diseases

Alias

Hypomyelinating Leukodystrophy

Hld	Leukodystrophy, Hypomyelinating

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07957	MAF1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MAF1	VGNC	VGNC:63363
Rattus norvegicus	MAF1	RGD	RGD:1359315
Bos taurus	MAF1	VGNC	VGNC:31137
Mus musculus	MAF1	MGD	MGI:1916127