2. Gene
  3. AFAP1L2 - actin filament associated protein 1 like 2 Gene

AFAP1L2 - actin filament associated protein 1 like 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as XB130; KIAA1914; CTB-1144G6.4

Gene ID: 84632 | Gene type: protein coding

About AFAP1L2

Cytogenetic location: 10q25.3 Genomic coordinates (GRCh38): 10:114,280,725-114,405,175 (from NCBI)

This gene has 7 transcripts (splice variants), 194 orthologues and 2 paralogues. Broad expression in thyroid (RPKM 34.2), spleen (RPKM 23.9) and 15 other tissues.

Summary

Enables SH2 domain binding activity; SH3 domain binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including positive regulation of epidermal growth factor receptor signaling pathway; regulation of gene expression; and regulation of mitotic cell cycle. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

AFAP1L2 Products(20)

mRNA Protein Name
NM_001001936.3 NP_001001936.1 actin filament-associated protein 1-like 2 isoform 1
NM_001287824.2 NP_001274753.1 actin filament-associated protein 1-like 2 isoform 3
NM_001351064.2 NP_001337993.1 actin filament-associated protein 1-like 2 isoform 4
NM_001351065.2 NP_001337994.1 actin filament-associated protein 1-like 2 isoform 5
NM_001351066.2 NP_001337995.1 actin filament-associated protein 1-like 2 isoform 6
NM_001351067.2 NP_001337996.1 actin filament-associated protein 1-like 2 isoform 7
NM_001351068.2 NP_001337997.1 actin filament-associated protein 1-like 2 isoform 8
NM_001351069.2 NP_001337998.1 actin filament-associated protein 1-like 2 isoform 9
NM_001351070.2 NP_001337999.1 actin filament-associated protein 1-like 2 isoform 10
NM_001351071.2 NP_001338000.1 actin filament-associated protein 1-like 2 isoform 11
NM_001351072.2 NP_001338001.1 actin filament-associated protein 1-like 2 isoform 12
NM_001351073.2 NP_001338002.1 actin filament-associated protein 1-like 2 isoform 13
NM_001351074.2 NP_001338003.1 actin filament-associated protein 1-like 2 isoform 14
NM_001351075.2 NP_001338004.1 actin filament-associated protein 1-like 2 isoform 15
NM_001351076.2 NP_001338005.1 actin filament-associated protein 1-like 2 isoform 16
NM_001351077.2 NP_001338006.1 actin filament-associated protein 1-like 2 isoform 17
NM_001351078.2 NP_001338007.1 actin filament-associated protein 1-like 2 isoform 18
NM_001351079.2 NP_001338008.1 actin filament-associated protein 1-like 2 isoform 19
NM_001351080.2 NP_001338009.1 actin filament-associated protein 1-like 2 isoform 20
NM_032550.4 NP_115939.1 actin filament-associated protein 1-like 2 isoform 2

AFAP1L2 Protein Structure

PH

PH: PH domain (181 - 269)

PH

PH: PH domain (365 - 439)

  • 0
  • 200
  • 400
  • 600
  • 818 a.a.
Protein Preferred Names Protein Names

actin filament-associated protein 1-like 2

AFAP1-like protein 2

Related Diseases

Diseases Alias
Vesicoureteral Reflux

Vesico-Ureteral Reflux
Cartilage Cancer

Chondrogenic Neoplasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00426 AFAP1L2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AFAP1L2 RGD RGD:1310668
Felis catus AFAP1L2 VGNC VGNC:59667
Bos taurus AFAP1L2 VGNC VGNC:25708
Canis familiaris AFAP1L2 VGNC VGNC:49824
Mus musculus AFAP1L2 MGD MGI:2147658
Macaca mulatta AFAP1L2 VGNC VGNC:69700