CREB3L3 - cAMP responsive element binding protein 3 like 3 Gene

Homo sapiens

Also known as CREBH; HYTG2; CREB-H; HYST1481

Gene ID: 84699 | Gene type: protein coding

About CREB3L3

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,153,631-4,173,054 (from NCBI)

This gene has 5 transcripts (splice variants), 246 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in small intestine (RPKM 71.0), duodenum (RPKM 67.5) and 1 other tissue.

Summary

This gene encodes a member of the basic-leucine zipper family and the AMP-dependent transcription factor family. The encoded protein is localized to the endoplasmic reticulum and acts as a transcription factor activated by cyclic AMP stimulation. The encoded protein binds the cyclic AMP response element (CRE) and the box-B element and has been linked to acute inflammatory response, hepatocellular carcinoma, triglyceride metabolism, and hepcidin expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

CREB3L3 Products(4)

mRNA	Protein	Name
NM_001271995.2	NP_001258924.1	cyclic AMP-responsive element-binding protein 3-like protein 3 isoform b
NM_001271996.2	NP_001258925.1	cyclic AMP-responsive element-binding protein 3-like protein 3 isoform c
NM_001271997.2	NP_001258926.1	cyclic AMP-responsive element-binding protein 3-like protein 3 isoform d
NM_032607.3	NP_115996.1	cyclic AMP-responsive element-binding protein 3-like protein 3 isoform a

CREB3L3 Protein Structure

bZIP_1

0
100
200
300
400
461 a.a.

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 3

CREB/ATF family transcription factor

Related Diseases

Diseases

Alias

Hypertriglyceridemia 2

HYTG2

Hypertriglyceridemia 1

Hypertriglyceridemia	Hypertriglyceridemia, Familial
Hypertriglyceridemia, Susceptibility To	HYTG1
FHTR	Hypertriglyceridemias Familial

Platyspondylic Lethal Skeletal Dysplasia, Torrance Type

PLSD-T	PLSDT
Platyspondylic Dysplasia, Torrance Type	Lethal Short-Limbed Platyspondylic Dwarfism, Torrance Type
Thanatophoric Dysplasia, Torrance Variant	Platyspondylic Skeletal Dysplasia, Torrance Type
Torrance Type Platyspondylic Dysplasia	Platyspondylic Dysplasia, Torrance-Luton Type
Platyspondylic Lethal Skeletal Dysplasia Torrance Type	Lethal Short-Limbed Platyspondylic Dwarfism Torrance Type
Thanatophoric Dysplasia Torrance Variant	Platyspondylic Chondrodysplasia, Torrance-Luton Type
Plsd-Tl	Dysplasia, Skeletal, Platyspondylic, Torrance Type

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Osteogenesis Imperfecta, Type Xix

OI19	Osteogenesis Imperfecta Type 19
Osteogenesis Imperfecta Type Xix	Osteogenesis Imperfecta, Type 19
Osteogenesis Imperfecta 19

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03152	CREB3L3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CREB3L3	RGD	RGD:1308152
Macaca mulatta	CREB3L3	VGNC	VGNC:109609
Canis familiaris	CREB3L3	VGNC	VGNC:54593
Mus musculus	CREB3L3	MGD	MGI:2384786
Bos taurus	CREB3L3	VGNC	VGNC:27696
Felis catus	CREB3L3	VGNC	VGNC:61168

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