2. Gene
  3. LINGO1 - leucine rich repeat and Ig domain containing 1 Gene

LINGO1 - leucine rich repeat and Ig domain containing 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LERN1; MRT64; LRRN6A; UNQ201

Gene ID: 84894 | Gene type: protein coding

About LINGO1

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,613,027-77,820,900 (from NCBI)

This gene has 14 transcripts (splice variants), 261 orthologues, 25 paralogues and is associated with 3 phenotypes. Biased expression in brain (RPKM 24.2), placenta (RPKM 1.9) and 3 other tissues.

Summary

Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. [provided by Alliance of Genome Resources, Apr 2022]

LINGO1 Products(12)

mRNA Protein Name
NM_001301186.2 NP_001288115.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301187.2 NP_001288116.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301189.2 NP_001288118.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301191.2 NP_001288120.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301192.2 NP_001288121.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301194.2 NP_001288123.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301195.2 NP_001288124.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301197.2 NP_001288126.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301198.2 NP_001288127.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301199.2 NP_001288128.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_001301200.2 NP_001288129.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor
NM_032808.7 NP_116197.4 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a precursor

LINGO1 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (120 - 179)

LRR_1

LRR_1: Leucine Rich Repeat (192 - 214)

LRR_1

LRR_1: Leucine Rich Repeat (289 - 308)

LRR_8

LRR_8: Leucine rich repeat (312 - 371)

I-set

I-set: Immunoglobulin I-set domain (429 - 514)

  • 0
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  • 620 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

leucine rich repeat neuronal 6A

Recombinant LINGO1 Proteins

Cat. No. Product Name Accession Purity
HY-P79417 LINGO-1 Protein, Human (HEK293, His) Q96FE5-1 (T40-T556) ≥95%

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, Autosomal Recessive 64

MRT64

Mental Retardation, Autosomal Recessive 64

Autosomal Recessive Intellectual Developmental Disorder 64

Mental Retardation, Autosomal Recessive, Type 64
Essential Tremor

Benign Essential Tremor

Familial Tremor

Hereditary Essential Tremor

Essential Hereditary Tremor

Shaky Hand Syndrome

Benign Essential Tremor Syndrome

Tremor Hereditary Essential

Essential Tremor, Susceptibility To

Tremor, Hereditary Essential
Tremor, Hereditary Essential, 1

ETM1

Fet1

Essential Tremor 1

Tremor, Familial Essential, 1

Essential Tremor, Hereditary, 1

Hereditary Essential Tremor 1

Tremor Hereditary Essential, 1

Tremor Familial Essential, 1

Tremor, Hereditary Essential 1

Tremor, Essential Hereditary, Type 1
Syndromic Intellectual Disability
Developmental And Epileptic Encephalopathy 24

DEE24

Epileptic Encephalopathy, Early Infantile, 24

Eiee24

Developmental And Epileptic Encephalopathy, 24

Early Infantile Epileptic Encephalopathy 24

Encephalopathy, Epileptic, Early Infantile, Type 24
Leber Optic Atrophy And Dystonia

LDYT

Marsden Syndrome

Leber Hereditary Optic Neuropathy With Dystonia

Leber Hereditary Optic Neuropathy And Dystonia

Familial Dystonia With Visual Failure And Striatal Lucencies

Dystonia, Familial, With Visual Failure And Striatal Lucencies

Leber Optic Atrophy With Dystonia

Dystonia Familial, With Visual Failure And Striatal Lucencies

Lhon And Dystonia

Leber'S Hereditary Optic Neuropathy With Dystonia
Primary Progressive Multiple Sclerosis

Ppms

Primary-Progressive Ms

Multiple Sclerosis, Primary Progressive
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Pelizaeus-Merzbacher Disease

PMD

HLD1

Pelizaeus-Merzbacher Brain Sclerosis

Leukodystrophy, Hypomyelinating, 1

Diffuse Familial Brain Sclerosis

Pelizaeus Merzbacher Brain Sclerosis

Sudanophilic Leukodystrophy, Paelizeus-Merzbacher Type

Cockayne-Pelizaeus-Merzbacher Disease

Hypomyelinating Leukodystrophy 1

Leukodystrophy, Sudanophilic

Pelizaeus Merzbacher Disease

Hypomyelinating Leukodystrophy, 1

Sudanophilic Leukodystrophy

Pelizaeus-Merzbacher Disease, Connatal Form

Connatal Pmd

Pelizaeus-Merzbacher Disease Type Ii

Severe Pmd

Null Syndrome

Plp1 Null Syndrome

Pelizaeus-Merzbacher Disease, Null Syndrome

Brain Sclerosis Diffuse Familial

Sudanophilic Leukodystrophy Paelizeus-Merzbacher Type

Leukodystrophy Hypomyelinating 1

Diffuse Cerebral Sclerosis Of Schilder
Optic Nerve Disease

Optic Neuropathy

Disorder Of The Second Nerve

Optic Nerve Disorder

Optic Nerve

Abnormality Of The Optic Nerve

Optic Nerve Disorders

Neuropathy, Optic

Disorder Of The Optic Nerve
Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease
Hypomyelinating Leukodystrophy

Hld

Leukodystrophy, Hypomyelinating
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07680 LINGO1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LINGO1 VGNC VGNC:74094
Bos taurus LINGO1 VGNC VGNC:30899
Canis familiaris LINGO1 VGNC VGNC:42688
Felis catus LINGO1 VGNC VGNC:63236
Mus musculus LINGO1 MGD MGI:1915522
Rattus norvegicus LINGO1 RGD RGD:1308668