2. Gene
  3. MAEL - maelstrom spermatogenic transposon silencer Gene

MAEL - maelstrom spermatogenic transposon silencer Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CT128; SPATA35

Gene ID: 84944 | Gene type: protein coding

About MAEL

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:166,975,582-167,022,214 (from NCBI)

This gene has 6 transcripts (splice variants) and 130 orthologues. Restricted expression toward testis (RPKM 61.7).

Summary

Predicted to enable sequence-specific DNA binding activity. Predicted to be involved in gamete generation; negative regulation of macromolecule metabolic process; and piRNA metabolic process. Predicted to act upstream of or within several processes, including homologous chromosome pairing at meiosis; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of macromolecule metabolic process. Predicted to be located in piP-body. Predicted to be active in P granule and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MAEL Products(3)

mRNA Protein Name
NM_001286377.2 NP_001273306.1 protein maelstrom homolog isoform 2
NM_001286378.2 NP_001273307.1 protein maelstrom homolog isoform 3
NM_032858.3 NP_116247.1 protein maelstrom homolog isoform 1

MAEL Protein Structure

HMG_box_2

HMG_box_2: HMG-box domain (2 - 70)

Maelstrom

Maelstrom: piRNA pathway germ-plasm component (130 - 326)

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  • 434 a.a.
Protein Preferred Names Protein Names

protein maelstrom homolog

cancer/testis antigen 128

Related Diseases

Diseases Alias
Astigmatism
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07955 MAEL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MAEL VGNC VGNC:63362
Mus musculus MAEL MGD MGI:2138453
Bos taurus MAEL VGNC VGNC:31136
Macaca mulatta MAEL VGNC VGNC:74362
Rattus norvegicus MAEL RGD RGD:1309333
Canis familiaris MAEL VGNC VGNC:42919