AJUBA - ajuba LIM protein Gene

Homo sapiens

Also known as JUB

Gene ID: 84962 | Gene type: protein coding

About AJUBA

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:22,971,177-22,982,551 (from NCBI)

This gene has 8 transcripts (splice variants), 171 orthologues and 2 paralogues. Broad expression in skin (RPKM 17.2), liver (RPKM 8.4) and 15 other tissues.

Summary

Enables alpha-catenin binding activity and transcription corepressor activity. Involved in several processes, including negative regulation of hippo signaling; positive regulation of gene silencing by miRNA; and regulation of cellular response to hypoxia. Acts upstream of or within gene silencing by miRNA and positive regulation of protein-containing complex assembly. Located in several cellular components, including Golgi apparatus; P-body; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

AJUBA Products(3)

mRNA	Protein	Name
NM_001289097.2	NP_001276026.1	LIM domain-containing protein ajuba isoform 3
NM_032876.6	NP_116265.1	LIM domain-containing protein ajuba isoform 1
NM_198086.3	NP_932352.1	LIM domain-containing protein ajuba isoform 2

AJUBA Protein Structure

LIM

0
100
200
300
400
500
538 a.a.

Protein Preferred Names

Protein Names

LIM domain-containing protein ajuba

jub, ajuba homolog

Related Diseases

Diseases

Alias

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00504	AJUBA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AJUBA	RGD	RGD:620407
Mus musculus	AJUBA	MGD	MGI:1341886
Felis catus	AJUBA	VGNC	VGNC:80777
Bos taurus	AJUBA	VGNC	VGNC:25769
Macaca mulatta	AJUBA	VGNC	VGNC:69645

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