2. Gene
  3. KHSRP - KH-type splicing regulatory protein Gene

KHSRP - KH-type splicing regulatory protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as p75; FBP2; KSRP; FUBP2

Gene ID: 8570 | Gene type: protein coding

About KHSRP

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,413,102-6,424,811 (from NCBI)

This gene has 12 transcripts (splice variants), 244 orthologues and 12 paralogues. Ubiquitous expression in testis (RPKM 37.2), endometrium (RPKM 25.1) and 25 other tissues.

Summary

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

KHSRP Products(3)

mRNA Protein Name
NM_001366299.1 NP_001353228.1 far upstream element-binding protein 2 isoform 2
NM_001366300.1 NP_001353229.1 far upstream element-binding protein 2 isoform 3
NM_003685.3 NP_003676.2 far upstream element-binding protein 2 isoform 1

KHSRP Protein Structure

KH_1

KH_1: KH domain (146 - 208)

KH_1

KH_1: KH domain (236 - 299)

KH_1

KH_1: KH domain (327 - 386)

KH_1

KH_1: KH domain (427 - 491)

DUF1897

DUF1897: Domain of unknown function (DUF1897) (611 - 632)

DUF1897

DUF1897: Domain of unknown function (DUF1897) (666 - 692)

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  • 711 a.a.
Protein Preferred Names Protein Names

far upstream element-binding protein 2

FUSE-binding protein 2

Related Diseases

Diseases Alias
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-124648 SMN-C2 98.85% Unkown
HY-RS07242 KHSRP Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KHSRP VGNC VGNC:42340
Mus musculus KHSRP MGD MGI:1336214
Macaca mulatta KHSRP VGNC VGNC:74015
Bos taurus KHSRP VGNC VGNC:30545
Felis catus KHSRP VGNC VGNC:67938
Rattus norvegicus KHSRP RGD RGD:621828