2. Gene
  3. SCARF1 - scavenger receptor class F member 1 Gene

SCARF1 - scavenger receptor class F member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SREC; SREC1; SREC-I

Gene ID: 8578 | Gene type: protein coding

About SCARF1

Cytogenetic location: 17p13.3 Genomic coordinates (GRCh38): 17:1,633,858-1,645,732 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 190 orthologues and 3 paralogues. Broad expression in spleen (RPKM 18.4), lung (RPKM 9.9) and 22 other tissues.

Summary

The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells. It regulates the uptake of chemically modified low density lipoproteins, including acetylated low density lipoprotein (Ac-LDL), and it may be involved in atherogenesis. This gene is regulated by the transcription factors ZNF444/EZF-2 and SP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

SCARF1 Products(2)

mRNA Protein Name
NM_003693.4 NP_003684.2 scavenger receptor class F member 1 isoform 1 precursor
NM_145350.3 NP_663325.1 scavenger receptor class F member 1 isoform 3 precursor

SCARF1 Protein Structure

hEGF

hEGF: Human growth factor-like EGF (75 - 86)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (103 - 130)

Laminin_EGF

Laminin_EGF: Laminin EGF domain (163 - 191)

hEGF

hEGF: Human growth factor-like EGF (236 - 248)

  • 0
  • 200
  • 400
  • 600
  • 830 a.a.
Protein Preferred Names Protein Names

scavenger receptor class F member 1

acetyl LDL receptor

Related Diseases

Diseases Alias
Acute Gonococcal Cervicitis

Gonococcal Cervicitis

Acute Gonorrhea Of Cervix
Acute Cervicitis
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset

EMARDD

Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset, Mild Variant

Early-Onset Myopathy-Areflexia-Respiratory Distress-Dysphagia Syndrome

Early-Onset Myopathy, Areflexia, Respiratory Distress And Dysphagia

Myopathy, Early-Onset, Areflexia, Respiratory Distress, And Dysphagia
Ophthalmia Neonatorum

Gonococcal Conjunctivitis

Gonococcal Ophthalmia Neonatorum

Neonatal Conjunctivitis
Van Den Ende-Gupta Syndrome

VDEGS

Blepharophimosis, Arachnodactyly, And Congenital Contractures

Marden-Walker-Like Syndrome

Marden-Walker-Like Syndrome Without Psychomotor Retardation

Marden Walker Like Syndrome

Marden-Walker-Like Syndrome Without Psychmotor Retardation

Van Den Ende Gupta Syndrome

Marden Walker Like Syndrome Without Psychomotor Retardation

Blepharophimosis Arachnodactyly And Congenital Contractures
Chromosome 17p13.3, Centromeric, Duplication Syndrome

Chromosome 17p13.3 Duplication Syndrome

17p13.3 Duplication Syndrome

17p13.3 Microduplication Syndrome

Trisomy 17p13.3

Chromosome 17p13.3 Centromeric Duplication Syndrome

Dup(17)(P13.3)
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12490 SCARF1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SCARF1 VGNC VGNC:77027
Felis catus SCARF1 VGNC VGNC:99445
Bos taurus SCARF1 VGNC VGNC:34326
Mus musculus SCARF1 MGD MGI:2449455
Rattus norvegicus SCARF1 RGD RGD:1309330