KLF7 - KLF transcription factor 7 Gene

Homo sapiens

Also known as UKLF

Gene ID: 8609 | Gene type: protein coding

About KLF7

Cytogenetic location: 2q33.3 Genomic coordinates (GRCh38): 2:207,074,137-207,173,851 (from NCBI)

This gene has 14 transcripts (splice variants), 270 orthologues, 22 paralogues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 4.7), endometrium (RPKM 4.4) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the Kruppel-like transcriptional regulator family. Members in this family regulate cell proliferation, differentiation and survival and contain three C2H2 zinc fingers at the C-terminus that mediate binding to GC-rich sites. This protein may contribute to the progression of type 2 diabetes by inhibiting Insulin expression and secretion in pancreatic beta-cells and by deregulating adipocytokine secretion in adipocytes. A pseudogene of this gene is located on the long arm of chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

KLF7 Products(4)

mRNA	Protein	Name
NM_001270942.1	NP_001257871.1	Krueppel-like factor 7 isoform 2
NM_001270943.2	NP_001257872.1	Krueppel-like factor 7 isoform 3
NM_001270944.2	NP_001257873.1	Krueppel-like factor 7 isoform 4
NM_003709.4	NP_003700.1	Krueppel-like factor 7 isoform 1

KLF7 Protein Structure

zf-H2C2_2

0
100
200
302 a.a.

Protein Preferred Names

Protein Names

Krueppel-like factor 7

Kruppel like factor 7

Related Diseases

Diseases

Alias

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07344	KLF7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	KLF7	RGD	RGD:1306029
Macaca mulatta	KLF7	VGNC	VGNC:81188
Bos taurus	KLF7	VGNC	VGNC:50537
Felis catus	KLF7	VGNC	VGNC:67955
Mus musculus	KLF7	MGD	MGI:1935151
Canis familiaris	KLF7	VGNC	VGNC:54965