NPFF - neuropeptide FF-amide peptide precursor Gene

Homo sapiens

Also known as FMRFAL

Gene ID: 8620 | Gene type: protein coding

About NPFF

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:53,506,688-53,507,484 (from NCBI)

This gene has 2 transcripts (splice variants) and 148 orthologues. Ubiquitous expression in skin (RPKM 3.8), spleen (RPKM 2.1) and 24 other tissues.

Summary

This gene encodes a member of the FMRFamide related peptide (FARP) family of neuropeptides. The encoded preproprotein is proteolytically processed to generate multiple amidated Peptides. These Peptides may play a role in the regulation of heart rate and blood pressure and the modulation of morphine-induced antinociception. Patients with hypertension exhibit decreased expression of the encoded protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

NPFF Products(2)

mRNA	Protein	Name
NM_001320296.2	NP_001307225.1	pro-FMRFamide-related neuropeptide FF isoform 2
NM_003717.4	NP_003708.1	pro-FMRFamide-related neuropeptide FF isoform 1 preproprotein

NPFF Protein Structure

NPFF

0
100
113 a.a.

Protein Preferred Names

Protein Names

pro-FMRFamide-related neuropeptide FF

Related Diseases

Diseases

Alias

Migraine With Aura

Classic Migraine	Migraine With Typical Aura
Migraine Accompagnée	Complicated Migraine
Classical Migraine	Acute Migraine With Aura

Opiate Dependence

Opioid Dependence	Opioid Addiction
Opiate Addiction	Opioid Type Dependence
Opioid-Related Disorders	Opium Dependence
Narcotic Dependence	Intravenous Narcotism
Narcotism Nos	Oral Narcotism Nos

Postsurgical Hypothyroidism

Postoperative Hypothyroidism

Post-Surgical Hypothyroidism

Pain Agnosia

Analgesia

N Syndrome

NSX	Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia

Withdrawal Disorder

Withdrawal Syndrome

Substance Withdrawal Syndrome

Agnosia

Dyspraxia	Primary Visual Agnosia
Dyspraxia Syndrome	Monomodal Visual Amnesia
Visual Amnesia	Agnosia, Primary Visual
Apraxias	Alexia

Opioid Abuse

Opioid-Related Disorders

Hermansky-Pudlak Syndrome 3

HPS3	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial
Delta Storage Pool Disease	Hermansky-Pudlak Syndrome, Type 3
Platelet Storage Pool Deficiency	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107726	BIBP3226 TFA	Antagonist	98.55%	Unkown
HY-P1248	Neuropeptide FF		99.26%	Unkown
HY-P1250	RFRP-3(human)	Agonist	99.21%	Unkown
HY-P1428	RFRP-1(human)	Agonist	99.67%	Unkown
HY-154829A	AC-099 hydrochloride		99.92%	Unkown
HY-107726A	BIBP3226	Antagonist	/	Unkown
HY-154829	AC-099		/	Unkown
HY-161382	NPFF2-R ligand 1		/	Unkown
HY-161405	NPFF1-R antagonist 1	Inhibitor	/	Unkown
HY-P1249	Neuropeptide SF(mouse,rat)	Agonist	/	Unkown
HY-P1249A	Neuropeptide SF(mouse,rat) TFA	Agonist	/	Unkown
HY-P1250A	RFRP-3(human) TFA	Agonist	/	Unkown
HY-P1428A	RFRP-1(human) TFA	Agonist	/	Unkown
HY-P3843	Neuropeptide AF (cattle)	Agonist	/	Unkown
HY-RS09480	NPFF Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NPFF	RGD	RGD:62033
Mus musculus	NPFF	MGD	MGI:1891708
Bos taurus	NPFF	VGNC	VGNC:32198

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