2. Gene
  3. ADAM19 - ADAM metallopeptidase domain 19 Gene

ADAM19 - ADAM metallopeptidase domain 19 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MLTNB; FKSG34; MADDAM

Gene ID: 8728 | Gene type: protein coding

About ADAM19

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,477,304-157,575,775 (from NCBI)

This gene has 5 transcripts (splice variants), 196 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 12.3), appendix (RPKM 11.1) and 18 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as Cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]

ADAM19 Products(1)

mRNA Protein Name
NM_033274.5 NP_150377.1 disintegrin and metalloproteinase domain-containing protein 19 preproprotein

ADAM19 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (44 - 162)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (210 - 408)

Disintegrin

Disintegrin: Disintegrin (425 - 499)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (502 - 617)

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  • 955 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 19

a disintegrin and metalloproteinase domain 19 (meltrin beta)

Related Diseases

Diseases Alias
Fanconi Renotubular Syndrome 1

Renal Fanconi Syndrome

Adult Fanconi Syndrome

FRTS1

Fanconi Renotubular Syndrome

Frts

Rfs

Fanconi Syndrome Without Cystinosis

Luder-Sheldon Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00275 ADAM19 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADAM19 VGNC VGNC:37577
Rattus norvegicus ADAM19 RGD RGD:1585017
Mus musculus ADAM19 MGD MGI:105377
Felis catus ADAM19 VGNC VGNC:59578
Bos taurus ADAM19 VGNC VGNC:25608
Macaca mulatta ADAM19 VGNC VGNC:69479
Others ADAM19 NCBI