2. Gene
  3. HRK - harakiri, BCL2 interacting protein Gene

HRK - harakiri, BCL2 interacting protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as DP5; HARAKIRI

Gene ID: 8739 | Gene type: protein coding

About HRK

Cytogenetic location: 12q24.22 Genomic coordinates (GRCh38): 12:116,856,144-116,881,441 (from NCBI)

This gene has 4 transcripts (splice variants) and 54 orthologues. Biased expression in brain (RPKM 5.1), thyroid (RPKM 2.9) and 3 other tissues.

Summary

This gene encodes a member of the Bcl-2 protein family. Members of this family are involved in activating or inhibiting Apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes Apoptosis by interacting with the apoptotic inhibitors Bcl-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]

HRK Products(1)

mRNA Protein Name
NM_003806.4 NP_003797.1 activator of apoptosis harakiri

HRK Protein Structure

Harakiri

Harakiri: Activator of apoptosis harakiri (1 - 91)

  • 0
  • 91 a.a.
Protein Preferred Names Protein Names

activator of apoptosis harakiri

BH3-interacting domain-containing protein 3

Related Diseases

Diseases Alias
Chronic Gonococcal Salpingitis

Gonococcal Salpingitis
Cycloplegia

Ciliary Muscle Paresis

Cycloplegic Paralysis Of Accommodation

Paresis Of Accommodation

Visual Accommodation Paralysis

Accommodation Paralysis

Intrinsic Paralysis Of Eye Muscle

Cycloplegic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P5342 Hrk BH3 / Unkown
HY-RS06371 HRK Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HRK VGNC VGNC:107709
Mus musculus HRK MGD MGI:1201608
Rattus norvegicus HRK RGD RGD:70549
Canis familiaris HRK VGNC VGNC:41789
Bos taurus HRK VGNC VGNC:29957