2. Gene
  3. TNFSF14 - TNF superfamily member 14 Gene

TNFSF14 - TNF superfamily member 14 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LTg; CD258; HVEML; LIGHT

Gene ID: 8740 | Gene type: protein coding

About TNFSF14

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:6,661,253-6,670,588 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 8 paralogues. Broad expression in liver (RPKM 1.5), appendix (RPKM 0.9) and 18 other tissues.

Summary

The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to Infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger Apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated Apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

TNFSF14 Products(3)

mRNA Protein Name
NM_001376887.1 NP_001363816.1 tumor necrosis factor ligand superfamily member 14 isoform 1
NM_003807.5 NP_003798.2 tumor necrosis factor ligand superfamily member 14 isoform 1
NM_172014.3 NP_742011.2 tumor necrosis factor ligand superfamily member 14 isoform 2

TNFSF14 Protein Structure

TNF

TNF: TNF(Tumour Necrosis Factor) family (113 - 240)

  • 0
  • 100
  • 200
  • 240 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor ligand superfamily member 14

herpesvirus entry mediator ligand

Recombinant TNFSF14 Proteins

Cat. No. Product Name Accession Purity
HY-P72033 LIGHT/TNFSF14 Protein, Human (HEK293, hFC-Myc) O43557 (D74-V240) ≥95%
HY-P72522 LIGHT/TNFSF14 Protein, Human (HEK293, His) AAC39563.1 (L83-V240) ≥95%
HY-P73281 LIGHT/TNFSF14 Protein, Human (HEK293, Fc) O43557 (D74-V240) ≥95%
HY-P78477 LIGHT/TNFSF14 Trimer Protein, Human (HEK293, His-Flag) O43557 (S89-V240) ≥95%
HY-P700136AF Animal-Free LIGHT/TNFSF14 Protein, Human (His) O43557 (R64-V240) ≥95%

Related Diseases

Diseases Alias
St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99810 Quisovalimab 96.18% Phase 2
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14825 TNFSF14 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TNFSF14 VGNC VGNC:36173
Macaca mulatta TNFSF14 VGNC VGNC:78595
Canis familiaris TNFSF14 VGNC VGNC:47670
Felis catus TNFSF14 VGNC VGNC:66414
Mus musculus TNFSF14 MGD MGI:1355317
Rattus norvegicus TNFSF14 RGD RGD:1588572
Others TNFSF14 NCBI