CCN5 - cellular communication network factor 5 Gene

Homo sapiens

Also known as CT58; WISP2; CTGF-L

Gene ID: 8839 | Gene type: protein coding

About CCN5

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:44,714,861-44,727,811 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 5 paralogues. Biased expression in ovary (RPKM 59.2), fat (RPKM 22.7) and 9 other tissues.

Summary

This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover. [provided by RefSeq, Jul 2008]

CCN5 Products(3)

mRNA	Protein	Name
NM_001323369.2	NP_001310298.1	CCN family member 5 isoform 2 precursor
NM_001323370.2	NP_001310299.1	CCN family member 5 isoform 1 precursor
NM_003881.4	NP_003872.1	CCN family member 5 isoform 1 precursor

CCN5 Protein Structure

IGFBP

VWC

TSP_1

0
100
200
250 a.a.

Protein Preferred Names

Protein Names

CCN family member 5

WNT1 inducible signaling pathway protein 2

Related Diseases

Diseases

Alias

Wilms Tumor 5

Wilms Tumor	WT5
Wilms Tumor Susceptibility-5	Wilms Tumor And Radial Bilateral Aplasia
Nephroblastoma	Wilms' Tumor
Wilms Tumor, Susceptibility To	Wtsl
Bilateral Radial Aplasia With Wilms Tumor	Embryonal Adenosarcoma
Embryonal Nephroma	Kidney Wilms Tumor
Kidney, Adenomyosarcoma, Embryonal	Kidney, Carcinosarcoma, Embryonal
Kidney, Embryoma	Kidney, Embryonal Mixed Tumor
Nephroma	Renal Adenosarcoma
Renal Cancer, Wilms	Renal Wilms Tumor
Tumor, Wilms	Hereditary Susceptibility To Wilms Tumor 5

Acth-Independent Macronodular Adrenal Hyperplasia

Acth-Independent Macronodular Adrenocortical Hyperplasia	Adrenocorticotropic Hormone-Independent Macronodular Adrenal Hyperplasia
Corticotropin-Independent Macronodular Adrenal Hyperplasia	Cushing Syndrome Due To Macronodular Adrenal Hyperplasia
AIMAH1	Aimah
Massive Macronodular Adrenocortical Disease	Mmad
Primary Macronodular Adrenal Hyperplasia	Cushing Syndrome, Adrenal, Due To Aimah
Primary Bilateral Macronodular Adrenal Hyperplasia	Acth-Independent Macronodular Adrenal Hyperplasia 1
Acth-Independent Cushing Syndrome	Adrenal Cushing Syndrome Due To Aimah
Acth-Independent Macronodular Adrenal Hyperplasia 2

Bladder Transitional Cell Papilloma

Bladder Papilloma	Transitional Cell Papilloma Of Bladder
Urinary Bladder Urothelial Papilloma	Urothelial Papilloma
Bladder Urothelial Papilloma

Primary Pigmented Nodular Adrenocortical Disease

Ppnad	Primary Pigmented Nodular Adrenal Dysplasia
Pigmented Nodular Adrenocortical Disease, Primary, 2	Pigmented Nodular Adrenocortical Disease, Primary, 1

Bladder Papillary Transitional Cell Neoplasm

Urinary Bladder Papillary Urothelial Neoplasm

Bladder Papillary Urothelial Neoplasm

Urinary Tract Papillary Transitional Cell Benign Neoplasm

Inverted Papilloma Of Urinary Tract	Papillary Transitional Cell Neoplasm Of The Urinary Tract
Urinary Tract Inverted Papilloma	Inverted Urothelial Papilloma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02114	CCN5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CCN5	RGD	RGD:621867
Felis catus	CCN5	VGNC	VGNC:60548
Mus musculus	CCN5	MGD	MGI:1328326
Macaca mulatta	CCN5	VGNC	VGNC:84569
Canis familiaris	CCN5	VGNC	VGNC:48415
Bos taurus	CCN5	VGNC	VGNC:36945

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