2. Gene
  3. SPHK1 - sphingosine kinase 1 Gene

SPHK1 - sphingosine kinase 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SPHK

Gene ID: 8877 | Gene type: protein coding

About SPHK1

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:76,383,204-76,387,855 (from NCBI)

This gene has 10 transcripts (splice variants), 277 orthologues and 4 paralogues. Ubiquitous expression in gall bladder (RPKM 4.9), esophagus (RPKM 4.2) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

SPHK1 Products(5)

mRNA Protein Name
NM_001142602.2 NP_001136074.1 sphingosine kinase 1 isoform 3
NM_021972.4 NP_068807.2 sphingosine kinase 1 isoform 1
NM_182965.3 NP_892010.2 sphingosine kinase 1 isoform 2
NM_001142601.2 NP_001136073.1 sphingosine kinase 1 isoform 3
NM_001355139.2 NP_001342068.1 sphingosine kinase 1 isoform 3

SPHK1 Protein Structure

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (16 - 137)

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  • 384 a.a.
Protein Preferred Names Protein Names

sphingosine kinase 1

SK 1

SPK 1

acetyltransferase SPHK1

Recombinant SPHK1 Proteins

Cat. No. Product Name Accession Purity
HY-P73421 SPHK1/Sphingosine Kinase 1 Protein, Human (sf9) Q9NYA1 (N-G&P, M1-L384) ≥95%
HY-P73631 SPHK1/Sphingosine Kinase 1 Protein, Human (sf9, His-GST) Q9NYA1 (M1-L384) ≥95%

Related Diseases

Diseases Alias
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Waardenburg Syndrome, Type 2b

Waardenburg Syndrome Type 2b

WS2B

Waardenburg Syndrome, Type Iib

Waardenburg Syndrome Type Iib
Renal Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15425A PF-543 Citrate Inhibitor 99.33% Unkown
HY-12892 SKI-178 Inhibitor 98.91% Unkown
HY-124042 K6PC-5 Activator 99.85% Unkown
HY-101572 MHP Activator 98.23% Unkown
HY-19794 MP-A08 Inhibitor ≥98.0% Unkown
HY-147282 Amgen-23 Inhibitor 99.00% Unkown
HY-119016A SK1-​I hydrochloride Inhibitor 99.49% Unkown
HY-148707 SphK1&2-IN-1 Inhibitor 99.33% Unkown
HY-150615 SphK1-IN-2 Inhibitor / Unkown
HY-148262 SphK1-IN-3 Inhibitor / Unkown
HY-143296 SphK1-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SPHK1 RGD RGD:620048
Mus musculus SPHK1 MGD MGI:1316649
Macaca mulatta SPHK1 VGNC VGNC:77858
Canis familiaris SPHK1 VGNC VGNC:49655
Felis catus SPHK1 VGNC VGNC:65635
Bos taurus SPHK1 VGNC VGNC:35210
Others SPHK1 NCBI