CDY1 - chromodomain Y-linked 1 Gene

Homo sapiens

Also known as CDY; CDY1A

Gene ID: 9085 | Gene type: protein coding

About CDY1

Cytogenetic location: Yq11.23 Genomic coordinates (GRCh38): Y:25,622,115-25,625,511 (from NCBI)

This gene has 2 transcripts (splice variants), 132 orthologues, 13 paralogues and is associated with 1 phenotype. Restricted expression toward testis (RPKM 2.1).

Summary

This gene encodes a protein containing a chromodomain and a Histone Acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

CDY1 Products(2)

mRNA	Protein	Name
NM_004680.3	NP_004671.1	testis-specific chromodomain protein Y 1 isoform b
NM_170723.2	NP_733841.1	testis-specific chromodomain protein Y 1 isoform a

CDY1 Protein Structure

Chromo

ECH_1

0
100
200
300
400
500
540 a.a.

Protein Preferred Names

Protein Names

testis-specific chromodomain protein Y 1

chromodomain protein, Y chromosome, 1

Related Diseases

Diseases

Alias

Spermatogenic Failure, Y-Linked, 2

SPGFY2	Spermatogenic Failure, Nonobstructive, Y-Linked
Y-Linked Spermatogenic Failure 2	Azoospermia, Nonobstructive, Y-Linked
Oligozoospermia, Nonobstructive, Y-Linked	Oligospermia, Nonobstructive, Y-Linked
Spermatogenic Arrest, Y-Linked	Nonobstructive Y-Linked Spermatogenic Failure
Spermatogenic Failure Y-Linked 2	Azoospermia Non-Obstructive Y-Linked
Non-Obstructive Azoospermia And Infertility	Oligospermia Non-Obstructive Y-Linked
Oligozoospermia Non-Obstructive Y-Linked	Spermatogenic Arrest Y-Linked
Spermatogenic Failure Nonobstructive Y-Linked