FMNL3 - formin like 3 Gene

Homo sapiens

Also known as FRL2; WBP3; FHOD3; WBP-3

Gene ID: 91010 | Gene type: protein coding

About FMNL3

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:49,636,499-49,707,405 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 18 paralogues. Ubiquitous expression in lymph node (RPKM 8.1), testis (RPKM 7.5) and 25 other tissues.

Summary

The protein encoded by this gene contains a formin homology 2 domain and has high sequence identity to the mouse Wbp3 protein. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

FMNL3 Products(3)

mRNA	Protein	Name
NM_001367835.1	NP_001354764.1	formin-like protein 3 isoform 3
NM_175736.5	NP_783863.4	formin-like protein 3 isoform 1
NM_198900.3	NP_944489.2	formin-like protein 3 isoform 2

FMNL3 Protein Structure

Drf_GBD

Drf_FH3

FH2

0
200
400
600
800
1027 a.a.

Protein Preferred Names

Protein Names

formin-like protein 3

WW domain binding protein 3

Related Diseases

Diseases

Alias

Malignant Breast Melanoma

Malignant Melanoma Of Breast

Breast Melanoma

Cerebral Amyloid Angiopathy, Itm2b-Related, 2

Dementia, Familial Danish	Fdd
Familial Danish Dementia	Heredopathia Ophthalmootoencephalica
Hooe	Cerebellar Ataxia, Cataract, Deafness, And Dementia Or Psychosis
Adan Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy 2
Itm2b Amyloidosis	Familial Cerebral Amyloid Angiopathy
Itm2b-Related Amyloidosis	Itm2b-Related Cerebral Amyloid Angiopathy
Familial Dementia, Danish Type	Cerebral Amyloid Angiopathy, Itm2b-Related 2
CAA-ITM2B2	Cerebellar Ataxia Cataract Deafness And Dementia Or Psychosis
Dementia, Familial, Danish

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05004	FMNL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FMNL3	RGD	RGD:1583854
Canis familiaris	FMNL3	VGNC	VGNC:40915
Bos taurus	FMNL3	VGNC	VGNC:29048
Mus musculus	FMNL3	MGD	MGI:109569
Macaca mulatta	FMNL3	VGNC	VGNC:72560
Felis catus	FMNL3	VGNC	VGNC:62306

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